EIF3D_CULQU
ID EIF3D_CULQU Reviewed; 612 AA.
AC B0X6P7;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 61.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit D {ECO:0000255|HAMAP-Rule:MF_03003};
DE Short=eIF3d {ECO:0000255|HAMAP-Rule:MF_03003};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 7 {ECO:0000255|HAMAP-Rule:MF_03003};
GN Name=eIF3-S7 {ECO:0000255|HAMAP-Rule:MF_03003}; ORFNames=CPIJ015133;
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB;
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C.M., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: mRNA cap-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation. In the
CC eIF-3 complex, eif3d specifically recognizes and binds the 7-
CC methylguanosine cap of a subset of mRNAs. {ECO:0000255|HAMAP-
CC Rule:MF_03003}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03003}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03003}.
CC -!- DOMAIN: The RNA gate region regulates mRNA cap recognition to prevent
CC promiscuous mRNA-binding before assembly of eif3d into the full
CC eukaryotic translation initiation factor 3 (eIF-3) complex.
CC {ECO:0000255|HAMAP-Rule:MF_03003}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit D family. {ECO:0000255|HAMAP-
CC Rule:MF_03003}.
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DR EMBL; DS232420; EDS41530.1; -; Genomic_DNA.
DR RefSeq; XP_001865319.1; XM_001865284.1.
DR AlphaFoldDB; B0X6P7; -.
DR SMR; B0X6P7; -.
DR STRING; 7176.CPIJ015133-PA; -.
DR PRIDE; B0X6P7; -.
DR EnsemblMetazoa; XM_001865284.2; XP_001865319.1; LOC6048395.
DR GeneID; 6048395; -.
DR KEGG; cqu:CpipJ_CPIJ015133; -.
DR VEuPathDB; VectorBase:CPIJ015133; -.
DR VEuPathDB; VectorBase:CQUJHB011028; -.
DR eggNOG; KOG2479; Eukaryota.
DR HOGENOM; CLU_024521_2_0_1; -.
DR InParanoid; B0X6P7; -.
DR OMA; PDGWGPC; -.
DR OrthoDB; 1030308at2759; -.
DR PhylomeDB; B0X6P7; -.
DR Proteomes; UP000002320; Partially assembled WGS sequence.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0098808; F:mRNA cap binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0002191; P:cap-dependent translational initiation; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR HAMAP; MF_03003; eIF3d; 1.
DR InterPro; IPR007783; eIF3d.
DR PANTHER; PTHR12399; PTHR12399; 1.
DR Pfam; PF05091; eIF-3_zeta; 1.
DR PIRSF; PIRSF016281; EIF-3_zeta; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW RNA-binding.
FT CHAIN 1..612
FT /note="Eukaryotic translation initiation factor 3 subunit
FT D"
FT /id="PRO_0000364141"
FT REGION 97..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 289..303
FT /note="RNA gate"
FT /evidence="ECO:0000250|UniProtKB:K7IM66"
FT REGION 584..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..116
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 596..612
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 612 AA; 68090 MW; 42E88664E50AF474 CRC64;
MSETIACTPE SVVFDAPQLQ FNEEGWGPCE LPDAFRDIPY QPFSKSDRLG KISDWTGTAQ
TDKKYSNKYN SQFGGGSQYA YYHEEDETTF HLVDSARVQK PPHQRGRFRG NMRGNRGRGR
GNRGGVQGGG MTNLSKNANK GRDQRRGTTR KWGNRMPPPK IRDASVAVRP DWVTIEEMDF
PRLSKLSLPS VKEGEDISTC GTLEYYDKVY DRVNVKNEKP LQRVDRIFHT VTTTDDPIIR
QLSKTHGNVY ATDSILATIM CCTRSNYSWD IVIEKIGDKL FMDKRDNTEF DLLTVNETAI
EPPQEDGNSL NSPRNLAIEA TFINHNFSQQ VLKSGEKETK FKFEDANPFI GDDEDGEVAS
VAYRYRKWDL NNGIVLVARC EHDAVLLTPQ GDTQFLTIKA LNEWDSKVAN GVEWRQKLDT
QRGAVLANEL RNNSCKLAKW TVQALLAGSD QIKFGYVSRA HVRDSSRHVI LGTQQFKPHE
FANQINLSMD NAWGILRCII DICMKQKDGK YLIMKDPNKP MIRLYDIPDH TFESDGEEEE
GDDETSAFQP YSYTAKPAAT AAAPAAVPTP VAAAAAPAAA PATAAAAVAA TPAEEAPKTT
TPTSAAAAVA QK
