EIF3D_XENTR
ID EIF3D_XENTR Reviewed; 552 AA.
AC Q6P8G0;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit D {ECO:0000255|HAMAP-Rule:MF_03003};
DE Short=eIF3d {ECO:0000255|HAMAP-Rule:MF_03003};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 7 {ECO:0000255|HAMAP-Rule:MF_03003};
GN Name=eif3d; Synonyms=eif3s7; ORFNames=TEgg054f16.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Egg;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: mRNA cap-binding component of the eukaryotic translation
CC initiation factor 3 (eIF-3) complex, which is involved in protein
CC synthesis of a specialized repertoire of mRNAs and, together with other
CC initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation. In the
CC eIF-3 complex, eif3d specifically recognizes and binds the 7-
CC methylguanosine cap of a subset of mRNAs. {ECO:0000255|HAMAP-
CC Rule:MF_03003}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c,
CC eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and
CC eif3m. {ECO:0000255|HAMAP-Rule:MF_03003}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03003}.
CC -!- DOMAIN: The RNA gate region regulates mRNA cap recognition to prevent
CC promiscuous mRNA-binding before assembly of eif3d into the full
CC eukaryotic translation initiation factor 3 (eIF-3) complex.
CC {ECO:0000255|HAMAP-Rule:MF_03003}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit D family. {ECO:0000255|HAMAP-
CC Rule:MF_03003}.
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DR EMBL; CR761224; CAJ81760.1; -; mRNA.
DR EMBL; BC061267; AAH61267.1; -; mRNA.
DR RefSeq; NP_989075.1; NM_203744.1.
DR AlphaFoldDB; Q6P8G0; -.
DR SMR; Q6P8G0; -.
DR STRING; 8364.ENSXETP00000056971; -.
DR PaxDb; Q6P8G0; -.
DR Ensembl; ENSXETT00000056971; ENSXETP00000056971; ENSXETG00000027259.
DR GeneID; 394672; -.
DR KEGG; xtr:394672; -.
DR CTD; 8664; -.
DR Xenbase; XB-GENE-942853; eif3d.
DR eggNOG; KOG2479; Eukaryota.
DR HOGENOM; CLU_024521_2_0_1; -.
DR InParanoid; Q6P8G0; -.
DR OMA; CKHNGVI; -.
DR OrthoDB; 1030308at2759; -.
DR PhylomeDB; Q6P8G0; -.
DR TreeFam; TF101519; -.
DR Reactome; R-XTR-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-XTR-72649; Translation initiation complex formation.
DR Reactome; R-XTR-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-XTR-72702; Ribosomal scanning and start codon recognition.
DR Proteomes; UP000008143; Chromosome 4.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000027259; Expressed in male organism and 28 other tissues.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:UniProtKB.
DR GO; GO:0098808; F:mRNA cap binding; ISS:UniProtKB.
DR GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
DR GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR GO; GO:0002191; P:cap-dependent translational initiation; ISS:UniProtKB.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006413; P:translational initiation; ISS:UniProtKB.
DR HAMAP; MF_03003; eIF3d; 1.
DR InterPro; IPR007783; eIF3d.
DR PANTHER; PTHR12399; PTHR12399; 1.
DR Pfam; PF05091; eIF-3_zeta; 1.
DR PIRSF; PIRSF016281; EIF-3_zeta; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW RNA-binding.
FT CHAIN 1..552
FT /note="Eukaryotic translation initiation factor 3 subunit
FT D"
FT /id="PRO_0000364136"
FT REGION 288..302
FT /note="RNA gate"
FT /evidence="ECO:0000250|UniProtKB:K7IM66"
FT REGION 526..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 530..552
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 552 AA; 64178 MW; C2E2B2AE228F2FBD CRC64;
MAKFQAPVIN DNPLGWGPCA VPDQFKDMPY QPFSKGDRLG KVADWTGATY QDKRYTNKYS
SQFGGGSQYA YFHDEDETSF QLVDTTKMQK TAYQRNRLRF AQRNLRRDKD RRNMLQFNMQ
TLPKSAKQKE RDRLRLQKKF QKQFGVRQKW DQKSQAQLKP RDSSVEVRSD WEVKEEMDFP
RLMKMRYMEV SDPLDIECCG ALEFYDKAFD RITTRNERPL KSIKRIFHTV TTTDDPVIRK
LAKTQGNVFA TDAILATLMC CTRSVNSWDI VVQRVGSKIF FDKRDNSDFD LLTVSETANE
PPQDDVNSLN SPRNLAMEAT YINHNFSQQC LRMGKEKHTF PNPNPFIEDD VDKNEVASVA
YRYRRWKLGD DIDLVVRCEH DGFMTGANGE VSFVNIKTLN EWDSRYCNGV DWRQKLDSQR
GAVIATELKN NSYKLARWTC CALLAGSEYL KLGYVSRCHV KDSTRHVVLG TQQFKPNEFA
NQINLSMENA WGILRCVVDI CMKLDEGKYL ILKDPNKQVI RIYSLPDGTF SSDEEDDDDD
EEEEEEVEEE ES
