EIF3E_ASPTN
ID EIF3E_ASPTN Reviewed; 446 AA.
AC Q0CNR3;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit E {ECO:0000255|HAMAP-Rule:MF_03004};
DE Short=eIF3e {ECO:0000255|HAMAP-Rule:MF_03004};
GN Name=int6; ORFNames=ATEG_04671;
OS Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=341663;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIH 2624 / FGSC A1156;
RA Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA Nierman W.C., Milne T., Madden K.;
RT "Annotation of the Aspergillus terreus NIH2624 genome.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03004}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03004}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03004}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit E family. {ECO:0000255|HAMAP-
CC Rule:MF_03004}.
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DR EMBL; CH476599; EAU35118.1; -; Genomic_DNA.
DR RefSeq; XP_001213849.1; XM_001213849.1.
DR AlphaFoldDB; Q0CNR3; -.
DR SMR; Q0CNR3; -.
DR STRING; 341663.Q0CNR3; -.
DR PRIDE; Q0CNR3; -.
DR EnsemblFungi; EAU35118; EAU35118; ATEG_04671.
DR GeneID; 4320481; -.
DR VEuPathDB; FungiDB:ATEG_04671; -.
DR eggNOG; KOG2758; Eukaryota.
DR HOGENOM; CLU_031132_0_0_1; -.
DR OMA; TWGKLAC; -.
DR OrthoDB; 1151808at2759; -.
DR Proteomes; UP000007963; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0071540; C:eukaryotic translation initiation factor 3 complex, eIF3e; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0070196; P:eukaryotic translation initiation factor 3 complex assembly; IEA:EnsemblFungi.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:EnsemblFungi.
DR HAMAP; MF_03004; eIF3e; 1.
DR InterPro; IPR016650; eIF3e.
DR InterPro; IPR019010; eIF3e_N.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10317; PTHR10317; 1.
DR Pfam; PF09440; eIF3_N; 1.
DR Pfam; PF01399; PCI; 1.
DR PIRSF; PIRSF016255; eIF3e_su6; 1.
DR SMART; SM01186; eIF3_N; 1.
DR SMART; SM00088; PINT; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..446
FT /note="Eukaryotic translation initiation factor 3 subunit
FT E"
FT /id="PRO_0000365983"
FT DOMAIN 256..425
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ SEQUENCE 446 AA; 51239 MW; 80F0105130CF82CF CRC64;
MAANVPPSAE TLLSGAAAHP PKTAEEIANQ YDLLPKLIPY LDRHLVFPLL EFSSGQDDDK
EVVRAKYELL KHTNMTDYVA NLWKEINNSD TIPDEFVKKR EEVLAKLENY QEESSKITEL
LQDEAVVGNL RSDKVANLRF LEEQHGVTLD MVNSLYDYGR FQYSCGSYGT AAELLYQFRV
LSTDNDKVAS ATWGKLASEI LTTSWEGAME EVQKVKESIE TRLFNNPLGQ LENRSWLIHW
SLFPFFNYDP ARDVLTDLFF SPAYINTIQT NCPWILRYLA AAVITNRNRA HKNSSAYQKQ
LKDLIRVVRQ EGYEYSDPIT DFVKALYIDF DFEEAQKKLG EAEDVLRSDF FLVSAADAFV
EAARHLISES YCKIHQRIDI KDLSTRLGLN QDEGEKWIVN LIRDTRVDAK IDYKEGTVIM
NHPPQSVYQQ VIEKTKGAFF RTQVLR