EIF3E_CAEEL
ID EIF3E_CAEEL Reviewed; 432 AA.
AC O61820;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit E {ECO:0000255|HAMAP-Rule:MF_03004};
DE Short=eIF3e {ECO:0000255|HAMAP-Rule:MF_03004};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 6 {ECO:0000255|HAMAP-Rule:MF_03004};
GN Name=eif-3.E {ECO:0000255|HAMAP-Rule:MF_03004}; ORFNames=B0511.10;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03004}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03004}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03004}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit E family. {ECO:0000255|HAMAP-
CC Rule:MF_03004}.
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DR EMBL; FO080219; CCD62105.1; -; Genomic_DNA.
DR PIR; T33118; T33118.
DR RefSeq; NP_492785.1; NM_060384.6.
DR AlphaFoldDB; O61820; -.
DR SMR; O61820; -.
DR BioGRID; 38371; 15.
DR IntAct; O61820; 2.
DR STRING; 6239.B0511.10; -.
DR EPD; O61820; -.
DR PaxDb; O61820; -.
DR PeptideAtlas; O61820; -.
DR EnsemblMetazoa; B0511.10.1; B0511.10.1; WBGene00001228.
DR GeneID; 172959; -.
DR KEGG; cel:CELE_B0511.10; -.
DR CTD; 172959; -.
DR WormBase; B0511.10; CE17349; WBGene00001228; eif-3.E.
DR eggNOG; KOG2758; Eukaryota.
DR GeneTree; ENSGT00390000002661; -.
DR HOGENOM; CLU_031132_0_1_1; -.
DR InParanoid; O61820; -.
DR OMA; TWGKLAC; -.
DR OrthoDB; 1151808at2759; -.
DR PhylomeDB; O61820; -.
DR Reactome; R-CEL-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-CEL-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-CEL-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-CEL-72702; Ribosomal scanning and start codon recognition.
DR PRO; PR:O61820; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00001228; Expressed in adult organism and 4 other tissues.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IBA:GO_Central.
DR GO; GO:0071540; C:eukaryotic translation initiation factor 3 complex, eIF3e; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006413; P:translational initiation; IBA:GO_Central.
DR HAMAP; MF_03004; eIF3e; 1.
DR InterPro; IPR016650; eIF3e.
DR InterPro; IPR019010; eIF3e_N.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10317; PTHR10317; 1.
DR Pfam; PF09440; eIF3_N; 1.
DR Pfam; PF01399; PCI; 1.
DR PIRSF; PIRSF016255; eIF3e_su6; 1.
DR SMART; SM01186; eIF3_N; 1.
DR SMART; SM00088; PINT; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..432
FT /note="Eukaryotic translation initiation factor 3 subunit
FT E"
FT /id="PRO_0000123518"
FT DOMAIN 221..401
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ SEQUENCE 432 AA; 50720 MW; 5489E810F201633F CRC64;
MSTFDLTQRM APFLDLHLII PLLEFIEPRG IYDEKSLTEM HRQLLTKTNM IDSVIETYNG
KPIPAAIEAK KKQIIKERDE LKSKVDSVVA ILEIPEVKEM MDNNRERDGN VRILEHLTQN
HNFTVDMVDT LFKYSKFMYE CGNYTVASVC LYYYRNLVNQ ADPNYLNALY GKLASEILLQ
EWEHARDDLL KLRAYIDANP FDTEWELVTQ RAWLMHWALF VYYNYPKGRD EIIEMFLNQQ
PYLNAIQVLA PHLLRYLAVA VVTSKSRQKN SLKDLVKVID IERHSYKDPV TDFLTCLYIK
YDFDEAQEML QKCEEVLSND FFLTAVLGDF RESARLLIFE MFCRIHQCIT IEMLARRLNM
SQEEAERWIV DLIRTYRIEG AKIDSKLGQV VMGVKSVSIH EQVMENTKRL TLRAQQIALQ
LEKGRQDKVK AT