ID   EIF3E_CRYNB             Reviewed;         463 AA.
AC   P0CN51; Q55IG0; Q5K7Z9;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit E {ECO:0000255|HAMAP-Rule:MF_03004};
DE            Short=eIF3e {ECO:0000255|HAMAP-Rule:MF_03004};
GN   Name=INT6 {ECO:0000255|HAMAP-Rule:MF_03004}; OrderedLocusNames=CNBM0600;
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03004}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03004}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03004}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit E family. {ECO:0000255|HAMAP-
CC       Rule:MF_03004}.
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DR   EMBL; AAEY01000062; EAL17493.1; -; Genomic_DNA.
DR   RefSeq; XP_772140.1; XM_767047.1.
DR   AlphaFoldDB; P0CN51; -.
DR   SMR; P0CN51; -.
DR   EnsemblFungi; AAW46818; AAW46818; CNM00700.
DR   EnsemblFungi; EAL17493; EAL17493; CNBM0600.
DR   GeneID; 4939420; -.
DR   KEGG; cnb:CNBM0600; -.
DR   VEuPathDB; FungiDB:CNBM0600; -.
DR   HOGENOM; CLU_031132_0_0_1; -.
DR   Proteomes; UP000001435; Chromosome 13.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0071540; C:eukaryotic translation initiation factor 3 complex, eIF3e; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_03004; eIF3e; 1.
DR   InterPro; IPR016650; eIF3e.
DR   InterPro; IPR019010; eIF3e_N.
DR   InterPro; IPR000717; PCI_dom.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR10317; PTHR10317; 1.
DR   Pfam; PF09440; eIF3_N; 1.
DR   Pfam; PF01399; PCI; 1.
DR   PIRSF; PIRSF016255; eIF3e_su6; 1.
DR   SMART; SM01186; eIF3_N; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50250; PCI; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis.
FT   CHAIN           1..463
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   E"
FT                   /id="PRO_0000410079"
FT   DOMAIN          224..407
FT                   /note="PCI"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
FT   REGION          432..463
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        437..454
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   463 AA;  52582 MW;  0D4D855F0AF52D3B CRC64;
     MADYDLTQKL IPHLDRHLAI PLLNHLSDIA IYPAEQLARA QYDLAKGTNM VNYVEQFHAQ
     IENAEPTDFA RLRDEATAKY QELQEKAQPV TKVIEDPDAV AKLRSGGDKD RNLDLLRSEY
     QIDIDQINAL YHFGQYQYSL GDYGSAGNLL YHFLILSPSY ELNISAQWGK LASNILNGEW
     DAALMQVRDL RETIDNPHGT SLAKPLAQLQ ARTWLLHWSL FVFFNLGENQ GCQGLLDMFL
     SPAYLNTIQT SCPHLLRYLV AAAIISRRAP KPANVRSRDH VKELTRIVET EEYQYTDPIT
     SFLKDVFADF DLTQAQQRLS VAESVVRSDF FLSGFADEFV ENARWLISEV ICRLHRRIDI
     GQLSKTLNLS NEEGEKWIVN LIRDSRMGVE AKIDLKENML HITRPHATPT ATLIETTRGL
     AFRSQAIQFA MQSSVGEPRE RGERGERGNK GGRGRPRTQE VAA