EIF3E_CULQU
ID EIF3E_CULQU Reviewed; 435 AA.
AC B0WAM5;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit E {ECO:0000255|HAMAP-Rule:MF_03004};
DE Short=eIF3e {ECO:0000255|HAMAP-Rule:MF_03004};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 6 {ECO:0000255|HAMAP-Rule:MF_03004};
GN Name=eIF3-S6; ORFNames=CPIJ003936;
OS Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Culicini; Culex; Culex.
OX NCBI_TaxID=7176;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JHB;
RG The Broad Institute Genome Sequencing Platform;
RA Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J., Mauceli E.,
RA Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA Fraser-Liggett C.M., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT "Annotation of Culex pipiens quinquefasciatus.";
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03004}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03004}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03004}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit E family. {ECO:0000255|HAMAP-
CC Rule:MF_03004}.
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DR EMBL; DS231873; EDS41579.1; -; Genomic_DNA.
DR RefSeq; XP_001845759.1; XM_001845707.1.
DR AlphaFoldDB; B0WAM5; -.
DR SMR; B0WAM5; -.
DR STRING; 7176.CPIJ003936-PA; -.
DR EnsemblMetazoa; XM_001845707.2; XP_001845759.1; LOC6035610.
DR GeneID; 6035610; -.
DR KEGG; cqu:CpipJ_CPIJ003936; -.
DR VEuPathDB; VectorBase:CPIJ003936; -.
DR VEuPathDB; VectorBase:CQUJHB002753; -.
DR eggNOG; KOG2758; Eukaryota.
DR HOGENOM; CLU_031132_0_1_1; -.
DR InParanoid; B0WAM5; -.
DR OMA; TWGKLAC; -.
DR OrthoDB; 1151808at2759; -.
DR PhylomeDB; B0WAM5; -.
DR Proteomes; UP000002320; Partially assembled WGS sequence.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0071540; C:eukaryotic translation initiation factor 3 complex, eIF3e; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR HAMAP; MF_03004; eIF3e; 1.
DR InterPro; IPR016650; eIF3e.
DR InterPro; IPR019010; eIF3e_N.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10317; PTHR10317; 1.
DR Pfam; PF09440; eIF3_N; 1.
DR Pfam; PF01399; PCI; 1.
DR PIRSF; PIRSF016255; eIF3e_su6; 1.
DR SMART; SM01186; eIF3_N; 1.
DR SMART; SM00088; PINT; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..435
FT /note="Eukaryotic translation initiation factor 3 subunit
FT E"
FT /id="PRO_0000365962"
FT DOMAIN 219..392
FT /note="PCI"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01185"
SQ SEQUENCE 435 AA; 51173 MW; 35825B993A91A9E6 CRC64;
MSKFDLTAKN CQYLDRHLTF PLLEFLLQKN IYDQTSLLKF ILETVSKTNM VDYTMDIRER
LNMGNELPEE LTKRRSNVLV KLKELQTEVA PLMKCMEELK NPDTMKDSKS IVHALQQEFD
FKYDIIRSAQ KLAKYLYECG NYRDSISYLY ICLLVMEPTD KNYLNVLWGK LAAEILTLNW
PTALEDLTRL RDFIDNHNFS PIEVLQQRTW LIHWSVLVFF NHAKGRDLII EMFLYKQLYL
NAIQTMCPHI LRYLATAVII NRGRRNALKD LIKIIQQESY TYKDPITEFL ECLYVNFDFE
GARMKLHECQ TVIINDFFII GCLQEFIENA RLMIFETFCR IHQCITIGML ADKLNMEPDE
AECWIVNLIR NARLDAKIDS KLGHVVMGTQ PLSPYQQLVE KIDSLSVRSE ALTVLVERKQ
KAKTQESGEG NWKYY
