ID   AFUMD_ASPFC             Reviewed;         373 AA.
AC   B0Y568;
DT   02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Zn(2)-C6 fungal-type transcription factor afumD {ECO:0000303|PubMed:30977375};
DE   AltName: Full=Fumihopaside A biosynthesis cluster protein D {ECO:0000303|PubMed:30977375};
GN   Name=afumD {ECO:0000303|PubMed:30977375}; ORFNames=AFUB_071570;
OS   Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus
OS   fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=451804;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CEA10 / CBS 144.89 / FGSC A1163;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
RN   [2]
RP   FUNCTION.
RX   PubMed=30977375; DOI=10.1021/acs.orglett.9b00984;
RA   Ma K., Zhang P., Tao Q., Keller N.P., Yang Y., Yin W.B., Liu H.;
RT   "Characterization and Biosynthesis of a Rare Fungal Hopane-Type
RT   Triterpenoid Glycoside Involved in the Antistress Property of Aspergillus
RT   fumigatus.";
RL   Org. Lett. 21:3252-3256(2019).
CC   -!- FUNCTION: Zn(2)-C6 fungal-type transcription factor; part of the gene
CC       cluster that mediates the biosynthesis fumihopaside A, a hopane-type
CC       glucoside that enhances the thermotolerance and UV resistance of
CC       N.fumigata. {ECO:0000269|PubMed:30977375}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR   EMBL; DS499598; EDP50817.1; -; Genomic_DNA.
DR   AlphaFoldDB; B0Y568; -.
DR   SMR; B0Y568; -.
DR   EnsemblFungi; EDP50817; EDP50817; AFUB_071570.
DR   VEuPathDB; FungiDB:AFUB_071570; -.
DR   HOGENOM; CLU_024934_6_0_1; -.
DR   PhylomeDB; B0Y568; -.
DR   Proteomes; UP000001699; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0008152; P:metabolic process; IEA:UniProt.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR021858; Fun_TF.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF11951; Fungal_trans_2; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..373
FT                   /note="Zn(2)-C6 fungal-type transcription factor afumD"
FT                   /id="PRO_0000452741"
FT   DNA_BIND        50..77
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          86..110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..25
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   373 AA;  41928 MW;  85EAE6A9B794A7C9 CRC64;
     MLDRSKMTSA IPDSNSSSSP RGHNQSERDS YNRKKRKGPR LAHRKSRTGC QRCRARRVKC
     DESRPVCRDC HRHGIPCVYD RPAEEGAIPP STGIQSRPLE PSPSDPSNDA HMELRLLHHF
     TLFTSATMPG AHLKRIKDCW SIDVPRLAFS YKPLLHAVFA IAALHLSKVN PDEAGLPDIH
     CNFLEQALRE HRLCIGGITT QTADAVCFTS ILLQIDVFAT LQSRHVVSYE QVSEWMRLVR
     GSVAVFDAAM EIVRHNTHPP NIWCIIDTFP MPLRTNSDAG SFSFLLPTVP DDEDDETALE
     AYRGAVAHIN ATWLAMEAKE HPQISCRRLM VFPLFVTAGF IDLLEKRRPR ALVPCPHHYV
     TYGGSETLHT NTS