ID   EIF3F_CAEEL             Reviewed;         294 AA.
AC   Q18967;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 146.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit F {ECO:0000255|HAMAP-Rule:MF_03005};
DE            Short=eIF3f {ECO:0000255|HAMAP-Rule:MF_03005};
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit 5 {ECO:0000255|HAMAP-Rule:MF_03005};
GN   Name=eif-3.F {ECO:0000255|HAMAP-Rule:MF_03005}; ORFNames=D2013.7;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=17411345; DOI=10.1371/journal.pgen.0030056;
RA   Curran S.P., Ruvkun G.;
RT   "Lifespan regulation by evolutionarily conserved genes essential for
RT   viability.";
RL   PLoS Genet. 3:E56-E56(2007).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03005}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03005}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03005}.
CC   -!- DISRUPTION PHENOTYPE: Extended lifespan in adults.
CC       {ECO:0000269|PubMed:17411345}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit F family. {ECO:0000255|HAMAP-
CC       Rule:MF_03005}.
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DR   EMBL; Z47808; CAA87773.1; -; Genomic_DNA.
DR   PIR; T20338; T20338.
DR   RefSeq; NP_495988.1; NM_063587.6.
DR   AlphaFoldDB; Q18967; -.
DR   SMR; Q18967; -.
DR   BioGRID; 39802; 22.
DR   DIP; DIP-25689N; -.
DR   IntAct; Q18967; 1.
DR   STRING; 6239.D2013.7; -.
DR   EPD; Q18967; -.
DR   PaxDb; Q18967; -.
DR   PeptideAtlas; Q18967; -.
DR   EnsemblMetazoa; D2013.7.1; D2013.7.1; WBGene00001229.
DR   GeneID; 174478; -.
DR   KEGG; cel:CELE_D2013.7; -.
DR   UCSC; D2013.7; c. elegans.
DR   CTD; 174478; -.
DR   WormBase; D2013.7; CE00932; WBGene00001229; eif-3.F.
DR   eggNOG; KOG2975; Eukaryota.
DR   GeneTree; ENSGT00950000183073; -.
DR   HOGENOM; CLU_027018_0_1_1; -.
DR   InParanoid; Q18967; -.
DR   OMA; MADTDSF; -.
DR   OrthoDB; 1038775at2759; -.
DR   PhylomeDB; Q18967; -.
DR   Reactome; R-CEL-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-CEL-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-CEL-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR   Reactome; R-CEL-72702; Ribosomal scanning and start codon recognition.
DR   PRO; PR:Q18967; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00001229; Expressed in larva and 4 other tissues.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IBA:GO_Central.
DR   GO; GO:0070122; F:isopeptidase activity; IEA:InterPro.
DR   GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0031369; F:translation initiation factor binding; IBA:GO_Central.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0006412; P:translation; IMP:UniProtKB.
DR   GO; GO:0006413; P:translational initiation; IBA:GO_Central.
DR   CDD; cd08064; MPN_eIF3f; 1.
DR   HAMAP; MF_03005; eIF3f; 1.
DR   InterPro; IPR027531; eIF3f.
DR   InterPro; IPR000555; JAMM/MPN+_dom.
DR   InterPro; IPR037518; MPN.
DR   InterPro; IPR024969; Rpn11/EIF3F_C.
DR   PANTHER; PTHR10540:SF6; PTHR10540:SF6; 1.
DR   Pfam; PF01398; JAB; 1.
DR   Pfam; PF13012; MitMem_reg; 1.
DR   SMART; SM00232; JAB_MPN; 1.
DR   PROSITE; PS50249; MPN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..294
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   F"
FT                   /id="PRO_0000364292"
FT   DOMAIN          7..155
FT                   /note="MPN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
SQ   SEQUENCE   294 AA;  32932 MW;  A8F2B2ED09AB33AF CRC64;
     MASNLTVNVH PGVYMNVVDT HMRRTKSSAK NTGQEKCMGT LMGYYEKGSI QVTNCFAIPF
     NESNDDLEID DQFNQQMISA LKKTSPNEQP VGWFLTTSDI TSSCLIYHDY YVRVITEASA
     RRESPPIVVL TIDTTFSGDM SKRMPVRAYL RSKAGIPGAA GPHCAIFNPL RVELAAFPGE
     LVAMQLIEKA LDSRRREATL ESGLEQLETS TAQMIEWLER MLHYVEDVNK NGEKPGDAQI
     GRQLMDIVTA SSNNMQPEKL DTLVKNTLRD YVMVSYLAKL TQTQLQVHER LVSA