ID   EIF3G_CAEBR             Reviewed;         261 AA.
AC   A8WLV5;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit G {ECO:0000255|HAMAP-Rule:MF_03006};
DE            Short=eIF3g {ECO:0000255|HAMAP-Rule:MF_03006};
DE   AltName: Full=Eukaryotic translation initiation factor 3 RNA-binding subunit {ECO:0000255|HAMAP-Rule:MF_03006};
DE            Short=eIF-3 RNA-binding subunit {ECO:0000255|HAMAP-Rule:MF_03006};
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit 4 {ECO:0000255|HAMAP-Rule:MF_03006};
GN   Name=eif-3.G.1 {ECO:0000255|HAMAP-Rule:MF_03006,
GN   ECO:0000312|WormBase:CBG00635};
GN   ORFNames=CBG00635 {ECO:0000312|WormBase:CBG00635};
GN   and
GN   Name=eif-3.G.2 {ECO:0000255|HAMAP-Rule:MF_03006,
GN   ECO:0000312|WormBase:CBG24970};
GN   ORFNames=CBG24970 {ECO:0000312|WormBase:CBG24970};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1] {ECO:0000312|EMBL:CAP21453.2}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16 {ECO:0000312|EMBL:CAP21453.2};
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC       initiation factor 3 (eIF-3) complex, which is involved in protein
CC       synthesis of a specialized repertoire of mRNAs and, together with other
CC       initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC       the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation. This
CC       subunit can bind 18S rRNA. {ECO:0000255|HAMAP-Rule:MF_03006}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03006}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03006}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit G family. {ECO:0000255|HAMAP-
CC       Rule:MF_03006}.
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DR   EMBL; HE600999; CAP22000.2; -; Genomic_DNA.
DR   EMBL; HE601195; CAP21453.2; -; Genomic_DNA.
DR   AlphaFoldDB; A8WLV5; -.
DR   SMR; A8WLV5; -.
DR   STRING; 6238.CBG00635; -.
DR   EnsemblMetazoa; CBG00635.1; CBG00635.1; WBGene00024001.
DR   EnsemblMetazoa; CBG24970.1; CBG24970.1; WBGene00042956.
DR   WormBase; CBG00635; CBP25767; WBGene00024001; Cbr-eif-3.G.1.
DR   WormBase; CBG24970; CBP25767; WBGene00042956; Cbr-eif-3.G.2.
DR   eggNOG; KOG0122; Eukaryota.
DR   HOGENOM; CLU_034595_0_0_1; -.
DR   InParanoid; A8WLV5; -.
DR   OMA; MQFIGSK; -.
DR   OrthoDB; 1226059at2759; -.
DR   Proteomes; UP000008549; Chromosome II.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   CDD; cd12933; eIF3G; 1.
DR   CDD; cd12408; RRM_eIF3G_like; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   HAMAP; MF_03006; eIF3g; 1.
DR   InterPro; IPR017334; eIF3_g.
DR   InterPro; IPR024675; eIF3g_N.
DR   InterPro; IPR034240; eIF3G_RRM.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF12353; eIF3g; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   PIRSF; PIRSF037949; Transl_init_eIF-3_RNA-bind; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW   RNA-binding.
FT   CHAIN           1..261
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   G"
FT                   /id="PRO_0000365030"
FT   DOMAIN          181..259
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03006"
FT   REGION          156..180
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   261 AA;  29619 MW;  91D64ED6DBF5D99D CRC64;
     MTGINLITSA PEVNSWAEAV EQDSAPHIQE GADGIRTETA FTEVDGVRYK VVTQFKVINK
     RVPKVVADRK KWVKFGSCKG EPAGPQVATT YVAEEVEMQF TRNRAGEQIL DVQEDKQAAK
     TTSREHCRHC KGNDHWSTHC PYKVMYQLDE EADANQDADS KNALGLRGDG RQMERNRSDE
     NTCRVTNLPQ EMNEDELRDV FGRIGRVIRI FIARDKITGL PKGFAFVTFE SRDDAARAIA
     ELNDIRMYHM VLKVEWTRPS N