ID   EIF3G_CAEEL             Reviewed;         262 AA.
AC   Q19706; K8ESE1;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2014, sequence version 2.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit G {ECO:0000255|HAMAP-Rule:MF_03006};
DE            Short=eIF3g {ECO:0000255|HAMAP-Rule:MF_03006};
DE   AltName: Full=Eukaryotic translation initiation factor 3 RNA-binding subunit {ECO:0000255|HAMAP-Rule:MF_03006};
DE            Short=eIF-3 RNA-binding subunit {ECO:0000255|HAMAP-Rule:MF_03006};
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit 4 {ECO:0000255|HAMAP-Rule:MF_03006};
GN   Name=eif-3.G {ECO:0000255|HAMAP-Rule:MF_03006};
GN   ORFNames=F22B5.2 {ECO:0000312|WormBase:F22B5.2a};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=12529635; DOI=10.1038/nature01278;
RA   Kamath R.S., Fraser A.G., Dong Y., Poulin G., Durbin R., Gotta M.,
RA   Kanapin A., Le Bot N., Moreno S., Sohrmann M., Welchman D.P., Zipperlen P.,
RA   Ahringer J.;
RT   "Systematic functional analysis of the Caenorhabditis elegans genome using
RT   RNAi.";
RL   Nature 421:231-237(2003).
CC   -!- FUNCTION: RNA-binding component of the eukaryotic translation
CC       initiation factor 3 (eIF-3) complex, which is involved in protein
CC       synthesis of a specialized repertoire of mRNAs and, together with other
CC       initiation factors, stimulates binding of mRNA and methionyl-tRNAi to
CC       the 40S ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation. This
CC       subunit can bind 18S rRNA. {ECO:0000255|HAMAP-Rule:MF_03006}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03006}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03006}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=a {ECO:0000312|WormBase:F22B5.2a};
CC         IsoId=Q19706-1; Sequence=Displayed;
CC       Name=b {ECO:0000312|WormBase:F22B5.2b};
CC         IsoId=Q19706-2; Sequence=VSP_056763;
CC   -!- DISRUPTION PHENOTYPE: Abnormal morphology (dumpy phenotype), slow
CC       growth, sterile and in severe cases embryonic lethal.
CC       {ECO:0000269|PubMed:12529635}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit G family. {ECO:0000255|HAMAP-
CC       Rule:MF_03006}.
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DR   EMBL; BX284602; CAA90354.1; -; Genomic_DNA.
DR   EMBL; BX284602; CCO25605.1; -; Genomic_DNA.
DR   PIR; T21238; T21238.
DR   RefSeq; NP_001263666.1; NM_001276737.1. [Q19706-1]
DR   RefSeq; NP_495778.1; NM_063377.3. [Q19706-2]
DR   AlphaFoldDB; Q19706; -.
DR   SMR; Q19706; -.
DR   BioGRID; 39675; 19.
DR   IntAct; Q19706; 1.
DR   STRING; 6239.F22B5.2a; -.
DR   EPD; Q19706; -.
DR   PaxDb; Q19706; -.
DR   PeptideAtlas; Q19706; -.
DR   EnsemblMetazoa; F22B5.2a.1; F22B5.2a.1; WBGene00001230. [Q19706-1]
DR   EnsemblMetazoa; F22B5.2b.1; F22B5.2b.1; WBGene00001230. [Q19706-2]
DR   GeneID; 174346; -.
DR   KEGG; cel:CELE_F22B5.2; -.
DR   CTD; 174346; -.
DR   WormBase; F22B5.2a; CE47869; WBGene00001230; eif-3.G. [Q19706-1]
DR   WormBase; F22B5.2b; CE02197; WBGene00001230; eif-3.G. [Q19706-2]
DR   eggNOG; KOG0122; Eukaryota.
DR   GeneTree; ENSGT00510000047802; -.
DR   InParanoid; Q19706; -.
DR   OMA; MQFIGSK; -.
DR   OrthoDB; 1226059at2759; -.
DR   PhylomeDB; Q19706; -.
DR   Reactome; R-CEL-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-CEL-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-CEL-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR   Reactome; R-CEL-72702; Ribosomal scanning and start codon recognition.
DR   PRO; PR:Q19706; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00001230; Expressed in larva and 4 other tissues.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   CDD; cd12933; eIF3G; 1.
DR   CDD; cd12408; RRM_eIF3G_like; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   HAMAP; MF_03006; eIF3g; 1.
DR   InterPro; IPR017334; eIF3_g.
DR   InterPro; IPR024675; eIF3g_N.
DR   InterPro; IPR034240; eIF3G_RRM.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   Pfam; PF12353; eIF3g; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   PIRSF; PIRSF037949; Transl_init_eIF-3_RNA-bind; 1.
DR   SMART; SM00360; RRM; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Cytoplasm; Initiation factor; Protein biosynthesis;
KW   Reference proteome; RNA-binding.
FT   CHAIN           1..262
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   G"
FT                   /id="PRO_0000123512"
FT   DOMAIN          182..260
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03006"
FT   VAR_SEQ         1..6
FT                   /note="Missing (in isoform b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_056763"
SQ   SEQUENCE   262 AA;  29877 MW;  5F31C32DC2D19E29 CRC64;
     MTGINAMAPA PEVVSWAEAV EQDNAPHIQE GADGTRTETA FTEVDGVRWK VVTQFKVINK
     RVPKVVADRK KWVKFGSCKG EPAGPQVATT YVAEEVDMQF TRNRAGEQIL DVQEDKQTAK
     TTSREHCRHC KGNDHWSTHC PYKVMYQLDE EADADKDTEK DRMAMGMRPD GRQIDRNRSD
     ENTCRVTNLP QEMNEDELRD LFGKIGRVIR IFIARDKVTG LPKGFAFVTF ESRDDAARAI
     AELNDIRMYH MVLKVEWTRP SN