ID   EIF3H_BOMMO             Reviewed;         337 AA.
AC   Q9GV27;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit H {ECO:0000255|HAMAP-Rule:MF_03007};
DE            Short=eIF3h {ECO:0000255|HAMAP-Rule:MF_03007};
OS   Bombyx mori (Silk moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Bombycidae; Bombycinae; Bombyx.
OX   NCBI_TaxID=7091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11222941; DOI=10.1016/s0965-1748(00)00124-7;
RA   Tsuzuki S., Iwami M., Sakurai S.;
RT   "Ecdysteroid-inducible genes in the programmed cell death during insect
RT   metamorphosis.";
RL   Insect Biochem. Mol. Biol. 31:321-331(2001).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03007}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03007}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03007}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit H family. {ECO:0000255|HAMAP-
CC       Rule:MF_03007}.
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DR   EMBL; AB041635; BAB16696.1; -; mRNA.
DR   RefSeq; NP_001036848.1; NM_001043383.2.
DR   AlphaFoldDB; Q9GV27; -.
DR   SMR; Q9GV27; -.
DR   STRING; 7091.BGIBMGA006141-TA; -.
DR   MEROPS; M67.971; -.
DR   EnsemblMetazoa; BGIBMGA006141-RA; BGIBMGA006141-TA; BGIBMGA006141.
DR   GeneID; 692388; -.
DR   KEGG; bmor:692388; -.
DR   CTD; 8667; -.
DR   eggNOG; KOG1560; Eukaryota.
DR   HOGENOM; CLU_044094_0_0_1; -.
DR   InParanoid; Q9GV27; -.
DR   OMA; KFNRYQQ; -.
DR   OrthoDB; 976469at2759; -.
DR   Proteomes; UP000005204; Unassembled WGS sequence.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0070122; F:isopeptidase activity; IEA:InterPro.
DR   GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   CDD; cd08065; MPN_eIF3h; 1.
DR   HAMAP; MF_03007; eIF3h; 1.
DR   InterPro; IPR027524; eIF3h.
DR   InterPro; IPR045810; eIF3h_C.
DR   InterPro; IPR000555; JAMM/MPN+_dom.
DR   InterPro; IPR037518; MPN.
DR   PANTHER; PTHR10410:SF3; PTHR10410:SF3; 1.
DR   Pfam; PF19445; eIF3h_C; 1.
DR   Pfam; PF01398; JAB; 1.
DR   SMART; SM00232; JAB_MPN; 1.
DR   PROSITE; PS50249; MPN; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..337
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   H"
FT                   /id="PRO_0000365183"
FT   DOMAIN          21..153
FT                   /note="MPN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
SQ   SEQUENCE   337 AA;  38610 MW;  0D1DB47D144AAC02 CRC64;
     MASRAGSARR APENEATIQY VQCDGLAVMK IVKHCHEESC SNMEVAQGAL LGLVVENRLE
     ITNCFPFPKH DDTMDEEEYQ LDMMRRLRRV NVDHFHVGWY QSADVGNFLS LSLLESQYHY
     QTSIEESVVV IYDTKKSARG FLTLKAYRLT PQAIAMYKEG DYTPEALRNL KIGYENLFIE
     VPIVIRNSPL TNIMISELTE MIPEEEGSKF LDLGTASVLE GQLRSLMERV DELNQEAIKF
     NRYQQLVVRQ QQDKHRWMVK RAQENAARAA KDETPLPEED VNKLFKPHPV PPRLNPMIVA
     GQIDTYSQHI SQFCSQSLAK LYLTQALQNA KEAKQNN