ID   EIF3H_BRUMA             Reviewed;         379 AA.
AC   A8QCY3;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit H {ECO:0000255|HAMAP-Rule:MF_03007};
DE            Short=eIF3h {ECO:0000255|HAMAP-Rule:MF_03007};
GN   ORFNames=Bm1_50170;
OS   Brugia malayi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17885136; DOI=10.1126/science.1145406;
RA   Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA   Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA   Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA   Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA   Pop M., White O., Barton G.J., Carlow C.K.S., Crawford M.J., Daub J.,
RA   Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA   Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.-W.,
RA   Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA   McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA   Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA   Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA   Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA   Blaxter M.L., Scott A.L.;
RT   "Draft genome of the filarial nematode parasite Brugia malayi.";
RL   Science 317:1756-1760(2007).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03007}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03007}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03007}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit H family. {ECO:0000255|HAMAP-
CC       Rule:MF_03007}.
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DR   EMBL; DS239429; EDP30182.1; -; Genomic_DNA.
DR   RefSeq; XP_001901502.1; XM_001901467.1.
DR   AlphaFoldDB; A8QCY3; -.
DR   SMR; A8QCY3; -.
DR   STRING; 6279.A8QCY3; -.
DR   GeneID; 6104918; -.
DR   CTD; 6104918; -.
DR   WormBase; Bm2693; BM29983; WBGene00222954; Bma-eif-3.H.
DR   InParanoid; A8QCY3; -.
DR   OrthoDB; 976469at2759; -.
DR   Proteomes; UP000006672; Unassembled WGS sequence.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0070122; F:isopeptidase activity; IEA:InterPro.
DR   GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   CDD; cd08065; MPN_eIF3h; 1.
DR   HAMAP; MF_03007; eIF3h; 1.
DR   InterPro; IPR027524; eIF3h.
DR   InterPro; IPR045810; eIF3h_C.
DR   InterPro; IPR000555; JAMM/MPN+_dom.
DR   InterPro; IPR037518; MPN.
DR   PANTHER; PTHR10410:SF3; PTHR10410:SF3; 1.
DR   Pfam; PF19445; eIF3h_C; 1.
DR   Pfam; PF01398; JAB; 1.
DR   SMART; SM00232; JAB_MPN; 1.
DR   PROSITE; PS50249; MPN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..379
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   H"
FT                   /id="PRO_0000365196"
FT   DOMAIN          17..170
FT                   /note="MPN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT   REGION          280..300
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        281..299
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   379 AA;  42316 MW;  0105227DC7ACD2AA CRC64;
     MSTISATVAG PSIVQFVQID SLVVMKIVKH VDSEMYAGLN EVAGEACQGL LTGLVSIDDR
     RLEITNCFPT ARAEPMLDGD EIAQNNAFYE EQKQAEMLDM LRKFRDMNID YELVGFYQAH
     PFGACFAQET IDSLIDYQAS VPDGVVLIYD PVKTRQGQLS IRAYRLSTKA LEMSLDGDWS
     PESTRTAGLT YENMLEELPV VIKNSHLVNV MLAELALEGD CAIQRSSSHL ELGTRRSLEK
     CLRSLMSDVD DLNRTVMAYT KYVADKQRYD LTVYNAMQKR QAENEQREAR GEPPLSFDDI
     KKMKPPQLTT KCGMLESFLC SSDARAHSDY AAEACLRHFS FSSFCLCFFN ENIAKLFLAE
     AVVDSHGSRD HGGAAASVR