ID   EIF3H_CAEBR             Reviewed;         365 AA.
AC   A8WVY9;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 3.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit H {ECO:0000255|HAMAP-Rule:MF_03007};
DE            Short=eIF3h {ECO:0000255|HAMAP-Rule:MF_03007};
GN   Name=eif-3.H {ECO:0000255|HAMAP-Rule:MF_03007,
GN   ECO:0000312|WormBase:CBG04003};
GN   ORFNames=CBG04003 {ECO:0000312|WormBase:CBG04003};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03007}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03007}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03007}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit H family. {ECO:0000255|HAMAP-
CC       Rule:MF_03007}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAP24801.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; HE600906; CAP24801.2; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_002639414.1; XM_002639368.1.
DR   AlphaFoldDB; A8WVY9; -.
DR   SMR; A8WVY9; -.
DR   STRING; 6238.CBG04003; -.
DR   EnsemblMetazoa; CBG04003.1; CBG04003.1; WBGene00026755.
DR   GeneID; 8581407; -.
DR   CTD; 8581407; -.
DR   WormBase; CBG04003; CBP14961; WBGene00026755; Cbr-eif-3.H.
DR   eggNOG; KOG1560; Eukaryota.
DR   HOGENOM; CLU_044094_0_0_1; -.
DR   InParanoid; A8WVY9; -.
DR   OrthoDB; 976469at2759; -.
DR   Proteomes; UP000008549; Chromosome I.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IBA:GO_Central.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IBA:GO_Central.
DR   GO; GO:0042788; C:polysomal ribosome; IBA:GO_Central.
DR   GO; GO:0070122; F:isopeptidase activity; IEA:InterPro.
DR   GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:InterPro.
DR   GO; GO:0008237; F:metallopeptidase activity; IBA:GO_Central.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   CDD; cd08065; MPN_eIF3h; 1.
DR   HAMAP; MF_03007; eIF3h; 1.
DR   InterPro; IPR027524; eIF3h.
DR   InterPro; IPR045810; eIF3h_C.
DR   InterPro; IPR000555; JAMM/MPN+_dom.
DR   InterPro; IPR037518; MPN.
DR   PANTHER; PTHR10410:SF3; PTHR10410:SF3; 1.
DR   Pfam; PF19445; eIF3h_C; 1.
DR   Pfam; PF01398; JAB; 1.
DR   SMART; SM00232; JAB_MPN; 1.
DR   PROSITE; PS50249; MPN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..365
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   H"
FT                   /id="PRO_0000365197"
FT   DOMAIN          15..166
FT                   /note="MPN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT   REGION          276..295
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        280..295
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   365 AA;  41034 MW;  3FFBBB45A7DC4F3C CRC64;
     MSTAVTITAP SVKHILLDSL VVMKIVKHVD SELHAGISEV SGDACAGVLT GLVFLEDSRL
     EITNCFPTVR NEPVIDDDAN AAQQYEEQKQ QEMLDMLRKF RTMNIDYEIV GFYQSHQFGA
     GFSHDLVESM FDYQAMGPEN VVLIYDPIKT RQGQLSIRAW RLSTAALDLA SKNDWRPELV
     KSAGLTYQNM FEELPIIIKS SYLNNVLMSE LALSKSYSSD KYSTRHFDLG SKKSLEKSVR
     AMMANVDELN KSIQSLTKYT IDKQRHDNMV FSLTQKRQQE NESRLARGDP PLPMDDIKRI
     KAPQLQTRNG LLDELLASFD TNALADFSKT VTSENITKLF IAEAVAEEKV VGTKDRTLSS
     VSSTR