ID   EIF3H_CAEEL             Reviewed;         365 AA.
AC   O01974;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 2.
DT   03-AUG-2022, entry version 140.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit H {ECO:0000255|HAMAP-Rule:MF_03007};
DE            Short=eIF3h {ECO:0000255|HAMAP-Rule:MF_03007};
GN   Name=eif-3.H {ECO:0000255|HAMAP-Rule:MF_03007}; ORFNames=C41D11.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03007}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03007}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03007}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit H family. {ECO:0000255|HAMAP-
CC       Rule:MF_03007}.
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DR   EMBL; FO080509; CCD64252.1; -; Genomic_DNA.
DR   PIR; T28786; T28786.
DR   RefSeq; NP_491370.1; NM_058969.4.
DR   AlphaFoldDB; O01974; -.
DR   SMR; O01974; -.
DR   BioGRID; 37513; 15.
DR   STRING; 6239.C41D11.2; -.
DR   World-2DPAGE; 0011:O01974; -.
DR   EPD; O01974; -.
DR   PaxDb; O01974; -.
DR   PeptideAtlas; O01974; -.
DR   EnsemblMetazoa; C41D11.2.1; C41D11.2.1; WBGene00001231.
DR   GeneID; 172044; -.
DR   KEGG; cel:CELE_C41D11.2; -.
DR   UCSC; C41D11.2; c. elegans.
DR   CTD; 172044; -.
DR   WormBase; C41D11.2; CE29220; WBGene00001231; eif-3.H.
DR   eggNOG; KOG1560; Eukaryota.
DR   GeneTree; ENSGT00730000111042; -.
DR   HOGENOM; CLU_044094_0_0_1; -.
DR   InParanoid; O01974; -.
DR   OMA; KFNRYQQ; -.
DR   OrthoDB; 976469at2759; -.
DR   PhylomeDB; O01974; -.
DR   Reactome; R-CEL-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-CEL-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-CEL-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR   Reactome; R-CEL-72702; Ribosomal scanning and start codon recognition.
DR   PRO; PR:O01974; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00001231; Expressed in adult organism and 4 other tissues.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IBA:GO_Central.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IBA:GO_Central.
DR   GO; GO:0042788; C:polysomal ribosome; IBA:GO_Central.
DR   GO; GO:0070122; F:isopeptidase activity; IEA:InterPro.
DR   GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:InterPro.
DR   GO; GO:0008237; F:metallopeptidase activity; IBA:GO_Central.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   CDD; cd08065; MPN_eIF3h; 1.
DR   HAMAP; MF_03007; eIF3h; 1.
DR   InterPro; IPR027524; eIF3h.
DR   InterPro; IPR045810; eIF3h_C.
DR   InterPro; IPR000555; JAMM/MPN+_dom.
DR   InterPro; IPR037518; MPN.
DR   PANTHER; PTHR10410:SF3; PTHR10410:SF3; 1.
DR   Pfam; PF19445; eIF3h_C; 1.
DR   Pfam; PF01398; JAB; 1.
DR   SMART; SM00232; JAB_MPN; 1.
DR   PROSITE; PS50249; MPN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..365
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   H"
FT                   /id="PRO_0000365198"
FT   DOMAIN          15..166
FT                   /note="MPN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
SQ   SEQUENCE   365 AA;  40965 MW;  01744132CB981E21 CRC64;
     MSTAVTITAP SVKHILLDSL VVMKIVKHVD SELHAGISEV SGDACAGVLT GLVFLEDSRL
     EITNCFPTVR NEPVMDDDAN AAQQYEEQKQ HEMLDMLRKF RTMNIDYEIV GFYQSHQFGA
     GFSHDLVESM FDYQAMGPEN VVLIYDPIKT RQGQLSLRAW RLSTAALDLA SKNDWRPELV
     KAAGLTYQNM FEELPIIIKS SYLNNVLMSE LSLAKSCSSD KYSTRHFDLG SKKSLEKSVR
     AMMANVDELN KSIQSLTKYT IDKQRHDNMV FSLTQKRQQE NESRVARGDP TIPMDDIKRI
     KAPQLQTRNG LLDELLASFD TNALADFSKT VTSENITKMF IAEAVAEEKV AGTKDRTLSS
     VSSTR