EIF3H_CHAGB
ID EIF3H_CHAGB Reviewed; 362 AA.
AC Q2GZK0;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit H {ECO:0000255|HAMAP-Rule:MF_03007};
DE Short=eIF3h {ECO:0000255|HAMAP-Rule:MF_03007};
GN ORFNames=CHGG_05046;
OS Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS NRRL 1970) (Soil fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX NCBI_TaxID=306901;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL Genome Announc. 3:E0002115-E0002115(2015).
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03007}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03007}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03007}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit H family. {ECO:0000255|HAMAP-
CC Rule:MF_03007}.
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DR EMBL; CH408032; EAQ88427.1; -; Genomic_DNA.
DR RefSeq; XP_001224260.1; XM_001224259.1.
DR AlphaFoldDB; Q2GZK0; -.
DR SMR; Q2GZK0; -.
DR STRING; 38033.XP_001224260.1; -.
DR EnsemblFungi; EAQ88427; EAQ88427; CHGG_05046.
DR GeneID; 4392750; -.
DR eggNOG; KOG1560; Eukaryota.
DR HOGENOM; CLU_044094_1_0_1; -.
DR InParanoid; Q2GZK0; -.
DR OMA; KFNRYQQ; -.
DR OrthoDB; 976469at2759; -.
DR Proteomes; UP000001056; Unassembled WGS sequence.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR CDD; cd08065; MPN_eIF3h; 1.
DR HAMAP; MF_03007; eIF3h; 1.
DR InterPro; IPR027524; eIF3h.
DR InterPro; IPR045810; eIF3h_C.
DR InterPro; IPR037518; MPN.
DR PANTHER; PTHR10410:SF3; PTHR10410:SF3; 1.
DR Pfam; PF19445; eIF3h_C; 2.
DR PROSITE; PS50249; MPN; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..362
FT /note="Eukaryotic translation initiation factor 3 subunit
FT H"
FT /id="PRO_0000365205"
FT DOMAIN 12..163
FT /note="MPN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
SQ SEQUENCE 362 AA; 40827 MW; D904361D936997A3 CRC64;
MCRASRRRSS HLYVPSQISD KDQVPRHHCS SSFPTTATGS IVGMDNNGVI EITNAFPFPT
VDVSGTDSHQ SDATSLAAAA PRAKANIAYQ NEMIRHLKEV NVDANNVGWY TSATMGNFIN
LSFIENQHHY QRDNDKTVAL VHDVSRSSQG ALSLRAFRLS PEFMAAFKEG KFTTESLQKS
KLTFRDILVE VPVVVHNSHL LTSFLHQIPA PPKSAEIPLP ASLEDIRRDP AQLPAHPSFD
TLDLSIDPFL EKTCDLLLDS IESHYSDLNN HQYYQRQLTR EQFKITQWQT KRKAENAARL
AAKQQPLPED EWQRLFKLPQ EPSRLEGMLN ARQVEQYSKQ VDGFTASITT KMFAVRGNLL
PE
