EIF3H_CHICK
ID EIF3H_CHICK Reviewed; 348 AA.
AC Q5ZLE6;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit H {ECO:0000255|HAMAP-Rule:MF_03007};
DE Short=eIF3h {ECO:0000255|HAMAP-Rule:MF_03007};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 3 {ECO:0000255|HAMAP-Rule:MF_03007};
DE AltName: Full=eIF-3-gamma;
DE AltName: Full=eIF3 p40 subunit {ECO:0000255|HAMAP-Rule:MF_03007};
GN Name=EIF3H {ECO:0000255|HAMAP-Rule:MF_03007};
GN Synonyms=EIF3S3 {ECO:0000255|HAMAP-Rule:MF_03007}; ORFNames=RCJMB04_6i8;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03007}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C,
CC EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and
CC EIF3M. {ECO:0000255|HAMAP-Rule:MF_03007}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03007}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit H family. {ECO:0000255|HAMAP-
CC Rule:MF_03007}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ719788; CAG31447.1; -; mRNA.
DR RefSeq; NP_001026122.1; NM_001030951.1.
DR AlphaFoldDB; Q5ZLE6; -.
DR SMR; Q5ZLE6; -.
DR BioGRID; 681277; 1.
DR STRING; 9031.ENSGALP00000025924; -.
DR MEROPS; M67.971; -.
DR PaxDb; Q5ZLE6; -.
DR Ensembl; ENSGALT00000088046; ENSGALP00000059292; ENSGALG00000040522.
DR GeneID; 420288; -.
DR KEGG; gga:420288; -.
DR CTD; 8667; -.
DR VEuPathDB; HostDB:geneid_420288; -.
DR eggNOG; KOG1560; Eukaryota.
DR GeneTree; ENSGT00730000111042; -.
DR HOGENOM; CLU_044094_0_0_1; -.
DR InParanoid; Q5ZLE6; -.
DR OMA; KFNRYQQ; -.
DR OrthoDB; 976469at2759; -.
DR PhylomeDB; Q5ZLE6; -.
DR TreeFam; TF101504; -.
DR Reactome; R-GGA-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-GGA-72702; Ribosomal scanning and start codon recognition.
DR PRO; PR:Q5ZLE6; -.
DR Proteomes; UP000000539; Chromosome 2.
DR Bgee; ENSGALG00000040522; Expressed in spleen and 13 other tissues.
DR ExpressionAtlas; Q5ZLE6; baseline and differential.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IBA:GO_Central.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:UniProtKB.
DR GO; GO:0042788; C:polysomal ribosome; IBA:GO_Central.
DR GO; GO:0070122; F:isopeptidase activity; IEA:InterPro.
DR GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:InterPro.
DR GO; GO:0008237; F:metallopeptidase activity; IBA:GO_Central.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006413; P:translational initiation; ISS:UniProtKB.
DR CDD; cd08065; MPN_eIF3h; 1.
DR HAMAP; MF_03007; eIF3h; 1.
DR InterPro; IPR027524; eIF3h.
DR InterPro; IPR045810; eIF3h_C.
DR InterPro; IPR000555; JAMM/MPN+_dom.
DR InterPro; IPR037518; MPN.
DR PANTHER; PTHR10410:SF3; PTHR10410:SF3; 1.
DR Pfam; PF19445; eIF3h_C; 1.
DR Pfam; PF01398; JAB; 1.
DR SMART; SM00232; JAB_MPN; 1.
DR PROSITE; PS50249; MPN; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..348
FT /note="Eukaryotic translation initiation factor 3 subunit
FT H"
FT /id="PRO_0000365174"
FT DOMAIN 35..169
FT /note="MPN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 266..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 348 AA; 39537 MW; 034A361FCA60FA61 CRC64;
MASRKEGSGA AGGGFGASKG KGKAATTGDS AVKQVQIDGL VVLKIIKHYQ EEGQGNEVVQ
GVLLGLVVDD RLEITNCFPF PQHTEDDADF DEVQYQMEMM RSLRHVNIDH LHVGWYQSTY
YGSFVTRALL DSQFSYQHAI EESVVLIYDP IKTAQGSLSL KAYRLTPKLM EVCKEKDFSP
EALKKANIAY ENMFEEVPIV IKNSYLINVM LWELEKKSAV ADRHELLSLA SSNHLGKSLQ
LLMDRVDEMS QDIVKYNTYL RNVSKQQQQK HQYQQRRQQE NLQRQSRGEA PLPEEDINKL
FKPPQPPARM ESLLIAGQIN TYCQNIKEFN AQNLGKLFMA QALQDYNN
