ID   EIF3H_DROER             Reviewed;         338 AA.
AC   B3N4F1;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit H {ECO:0000255|HAMAP-Rule:MF_03007};
DE            Short=eIF3h {ECO:0000255|HAMAP-Rule:MF_03007};
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit 3 {ECO:0000255|HAMAP-Rule:MF_03007};
GN   Name=eIF-3p40 {ECO:0000255|HAMAP-Rule:MF_03007};
GN   Synonyms=eif3-S3 {ECO:0000255|HAMAP-Rule:MF_03007}; ORFNames=GG24322;
OS   Drosophila erecta (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7220;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14021-0224.01;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03007}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. The eIF-3 complex interacts with pix. Interacts with
CC       mxt (By similarity). {ECO:0000250|UniProtKB:Q9U9Q4, ECO:0000255|HAMAP-
CC       Rule:MF_03007}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03007}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit H family. {ECO:0000255|HAMAP-
CC       Rule:MF_03007}.
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DR   EMBL; CH954177; EDV57821.1; -; Genomic_DNA.
DR   RefSeq; XP_001968762.1; XM_001968726.2.
DR   AlphaFoldDB; B3N4F1; -.
DR   SMR; B3N4F1; -.
DR   STRING; 7220.FBpp0142868; -.
DR   MEROPS; M67.971; -.
DR   EnsemblMetazoa; FBtr0144376; FBpp0142868; FBgn0116454.
DR   GeneID; 6540592; -.
DR   KEGG; der:6540592; -.
DR   eggNOG; KOG1560; Eukaryota.
DR   HOGENOM; CLU_044094_0_0_1; -.
DR   OMA; KFNRYQQ; -.
DR   OrthoDB; 976469at2759; -.
DR   PhylomeDB; B3N4F1; -.
DR   ChiTaRS; eIF-3p40; fly.
DR   Proteomes; UP000008711; Unassembled WGS sequence.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0070122; F:isopeptidase activity; IEA:InterPro.
DR   GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0045747; P:positive regulation of Notch signaling pathway; IEA:EnsemblMetazoa.
DR   CDD; cd08065; MPN_eIF3h; 1.
DR   HAMAP; MF_03007; eIF3h; 1.
DR   InterPro; IPR027524; eIF3h.
DR   InterPro; IPR045810; eIF3h_C.
DR   InterPro; IPR000555; JAMM/MPN+_dom.
DR   InterPro; IPR037518; MPN.
DR   PANTHER; PTHR10410:SF3; PTHR10410:SF3; 1.
DR   Pfam; PF19445; eIF3h_C; 1.
DR   Pfam; PF01398; JAB; 1.
DR   SMART; SM00232; JAB_MPN; 1.
DR   PROSITE; PS50249; MPN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis.
FT   CHAIN           1..338
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   H"
FT                   /id="PRO_0000365186"
FT   DOMAIN          22..154
FT                   /note="MPN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
SQ   SEQUENCE   338 AA;  38346 MW;  E7269C54EFC7E939 CRC64;
     MANRANRHAA RTEDSDNTIN YVQCDGLAVM KMVKHCHEES SNMDLAQGAL LGLVVDKCLE
     ITNCFPFPKS GDETMDEELY QLTVMRRLRR VNVDHLHVGW YQSSDVGNSL SLALLESQYH
     YQTSIEESVV VVYDTQKSSR GFLCLKAYRL TPQAIQMYKD GDFTPEAFRT LKVGYESLFA
     EIPIVIKNSP LTNIMMSELN ELLPEDKGHN FLDLGTATVL ENQMRSLIER VDELYQEAVR
     YNKYQQVVFK QDTEKHRALA KLAAENAVRT SKGEPTVPEE EVIKQFRPMT APNRLTATIT
     SGQINTHAQH IAQFCSQSLA KLFITESLQN AKEAKETK