EIF3H_DROPS
ID EIF3H_DROPS Reviewed; 337 AA.
AC B5DJJ2;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 1.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit H {ECO:0000255|HAMAP-Rule:MF_03007};
DE Short=eIF3h {ECO:0000255|HAMAP-Rule:MF_03007};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 3 {ECO:0000255|HAMAP-Rule:MF_03007};
GN Name=eIF-3p40 {ECO:0000255|HAMAP-Rule:MF_03007};
GN Synonyms=eif3-S3 {ECO:0000255|HAMAP-Rule:MF_03007}; ORFNames=GA28878;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03007}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. The eIF-3 complex interacts with pix. Interacts with
CC mxt (By similarity). {ECO:0000250|UniProtKB:Q9U9Q4, ECO:0000255|HAMAP-
CC Rule:MF_03007}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03007}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit H family. {ECO:0000255|HAMAP-
CC Rule:MF_03007}.
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DR EMBL; CH379061; EDY70464.1; -; Genomic_DNA.
DR RefSeq; XP_002133062.1; XM_002133026.2.
DR AlphaFoldDB; B5DJJ2; -.
DR SMR; B5DJJ2; -.
DR STRING; 7237.FBpp0287566; -.
DR MEROPS; M67.971; -.
DR EnsemblMetazoa; FBtr0289128; FBpp0287566; FBgn0250237.
DR GeneID; 6902520; -.
DR KEGG; dpo:Dpse_GA28878; -.
DR eggNOG; KOG1560; Eukaryota.
DR HOGENOM; CLU_044094_0_0_1; -.
DR InParanoid; B5DJJ2; -.
DR OMA; KFNRYQQ; -.
DR ChiTaRS; eIF-3p40; fly.
DR Proteomes; UP000001819; Chromosome 4.
DR Bgee; FBgn0250237; Expressed in female reproductive system and 2 other tissues.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0070122; F:isopeptidase activity; IEA:InterPro.
DR GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0045747; P:positive regulation of Notch signaling pathway; IEA:EnsemblMetazoa.
DR CDD; cd08065; MPN_eIF3h; 1.
DR HAMAP; MF_03007; eIF3h; 1.
DR InterPro; IPR027524; eIF3h.
DR InterPro; IPR045810; eIF3h_C.
DR InterPro; IPR000555; JAMM/MPN+_dom.
DR InterPro; IPR037518; MPN.
DR PANTHER; PTHR10410:SF3; PTHR10410:SF3; 1.
DR Pfam; PF19445; eIF3h_C; 1.
DR Pfam; PF01398; JAB; 1.
DR SMART; SM00232; JAB_MPN; 1.
DR PROSITE; PS50249; MPN; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..337
FT /note="Eukaryotic translation initiation factor 3 subunit
FT H"
FT /id="PRO_0000365190"
FT DOMAIN 21..153
FT /note="MPN"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
SQ SEQUENCE 337 AA; 38132 MW; 901B518B783D5371 CRC64;
MANRGGRHAR TEDSDNTINY VQCDGLAVMK MVKHCHEESS NMDLAQGALL GLVVDKCLEI
TNCFPFPKSG DETMDEEMYQ LTVMRRLRRV NVDHLHVGWY QSSDVGNSLS LALLESQYHY
QTSIEESVVV VYDTQKSARG FLCLKAYRLT PQAIQMYKDG DFTPEAFRTL KVGYESLFAE
IPIVIKNSPL TNIMMSELNE LLPEDKGHNF LDLGTASVLE NHMRSLIERV DELYQEAVRY
NKYQQVVFKQ DSDKNRALAK LAAENAVRTS KGEPTVAEEE VIKQFRPMPV PARLTATITS
GQINTHSQHI AQFCSQSLAK LFITESLQNA KEAKEIK
