ID   EIF3H_DROVI             Reviewed;         337 AA.
AC   B4LTW0;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit H {ECO:0000255|HAMAP-Rule:MF_03007};
DE            Short=eIF3h {ECO:0000255|HAMAP-Rule:MF_03007};
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit 3 {ECO:0000255|HAMAP-Rule:MF_03007};
GN   Name=eIF-3p40 {ECO:0000255|HAMAP-Rule:MF_03007};
GN   Synonyms=eif3-S3 {ECO:0000255|HAMAP-Rule:MF_03007}; ORFNames=GJ10133;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15010-1051.87;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03007}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. The eIF-3 complex interacts with pix. Interacts with
CC       mxt (By similarity). {ECO:0000250|UniProtKB:Q9U9Q4, ECO:0000255|HAMAP-
CC       Rule:MF_03007}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03007}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit H family. {ECO:0000255|HAMAP-
CC       Rule:MF_03007}.
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DR   EMBL; CH940649; EDW64011.1; -; Genomic_DNA.
DR   RefSeq; XP_002051856.1; XM_002051820.2.
DR   AlphaFoldDB; B4LTW0; -.
DR   SMR; B4LTW0; -.
DR   STRING; 7244.FBpp0224550; -.
DR   MEROPS; M67.971; -.
DR   EnsemblMetazoa; FBtr0226058; FBpp0224550; FBgn0197421.
DR   GeneID; 6628544; -.
DR   KEGG; dvi:6628544; -.
DR   eggNOG; KOG1560; Eukaryota.
DR   HOGENOM; CLU_044094_0_0_1; -.
DR   InParanoid; B4LTW0; -.
DR   OMA; KFNRYQQ; -.
DR   OrthoDB; 976469at2759; -.
DR   PhylomeDB; B4LTW0; -.
DR   ChiTaRS; eIF-3p40; fly.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0070122; F:isopeptidase activity; IEA:InterPro.
DR   GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:InterPro.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0045747; P:positive regulation of Notch signaling pathway; IEA:EnsemblMetazoa.
DR   CDD; cd08065; MPN_eIF3h; 1.
DR   HAMAP; MF_03007; eIF3h; 1.
DR   InterPro; IPR027524; eIF3h.
DR   InterPro; IPR045810; eIF3h_C.
DR   InterPro; IPR000555; JAMM/MPN+_dom.
DR   InterPro; IPR037518; MPN.
DR   PANTHER; PTHR10410:SF3; PTHR10410:SF3; 1.
DR   Pfam; PF19445; eIF3h_C; 1.
DR   Pfam; PF01398; JAB; 1.
DR   SMART; SM00232; JAB_MPN; 1.
DR   PROSITE; PS50249; MPN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT   CHAIN           1..337
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   H"
FT                   /id="PRO_0000365192"
FT   DOMAIN          21..153
FT                   /note="MPN"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01182"
SQ   SEQUENCE   337 AA;  38254 MW;  09AD6272A04340B3 CRC64;
     MANRGARHAR TEDSDNTINY VQCDGLAVMK MVKHCHEESS NMDLAQGALL GLVVDKCLEI
     TNCFPFPKSG DETMDEEMYQ LTVMRRLRRV NVDHLHVGWY QSSDVGNSLS LALLESQYHY
     QTSIEESVVV VYDTQKSSRG FLCLKAYRLT PQAIQMYKDG DFTPEAFRTL KVGYESLFAE
     IPIVIKNSPL TNIMMSELNE LLPEDKGHNF LDLGTASVLE NHMRSLIERV DELYQEAVRY
     NKYQQVVFKQ DTEKHRALAK LAAENAVRTS KGEPTVPEEE VIKQFRPMPV PARLTATITS
     GQINTHAQHI AQFCSQSLAK LFITESLQNA KETKEIK