ID   EIF3I_ASHGO             Reviewed;         346 AA.
AC   Q759L2;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 123.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit I {ECO:0000255|HAMAP-Rule:MF_03008};
DE            Short=eIF3i {ECO:0000255|HAMAP-Rule:MF_03008};
DE   AltName: Full=Eukaryotic translation initiation factor 3 39 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03008};
DE            Short=eIF-3 39 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03008};
GN   Name=TIF34 {ECO:0000255|HAMAP-Rule:MF_03008}; OrderedLocusNames=ADR264C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03008}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03008}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03008}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit I family. {ECO:0000255|HAMAP-
CC       Rule:MF_03008}.
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DR   EMBL; AE016817; AAS52184.1; -; Genomic_DNA.
DR   RefSeq; NP_984360.1; NM_209713.1.
DR   AlphaFoldDB; Q759L2; -.
DR   SMR; Q759L2; -.
DR   STRING; 33169.AAS52184; -.
DR   EnsemblFungi; AAS52184; AAS52184; AGOS_ADR264C.
DR   GeneID; 4620522; -.
DR   KEGG; ago:AGOS_ADR264C; -.
DR   eggNOG; KOG0643; Eukaryota.
DR   HOGENOM; CLU_043845_0_1_1; -.
DR   InParanoid; Q759L2; -.
DR   OMA; VWFSHNG; -.
DR   Proteomes; UP000000591; Chromosome IV.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0071540; C:eukaryotic translation initiation factor 3 complex, eIF3e; IEA:EnsemblFungi.
DR   GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IBA:GO_Central.
DR   GO; GO:0034399; C:nuclear periphery; IEA:EnsemblFungi.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR   GO; GO:0002183; P:cytoplasmic translational initiation; IBA:GO_Central.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03008; eIF3i; 1.
DR   InterPro; IPR027525; eIF3i.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW   Repeat; WD repeat.
FT   CHAIN           1..346
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   I"
FT                   /id="PRO_0000365354"
FT   REPEAT          8..47
FT                   /note="WD 1"
FT   REPEAT          50..89
FT                   /note="WD 2"
FT   REPEAT          150..189
FT                   /note="WD 3"
FT   REPEAT          192..233
FT                   /note="WD 4"
FT   REPEAT          289..328
FT                   /note="WD 5"
SQ   SEQUENCE   346 AA;  38601 MW;  1899152F7680D7BF CRC64;
     MRPIMLMGHE RSLTQVKYNR EGDLIFTSGK DNVASVWYAM NGERLGTLEG HNGSIWSIDV
     DQHTEYAVTG SADFSVKVWR VRDGSIAHSW DTRTPVRRVE FSPTGDRVLA VLDNVMNYAG
     AIVVFSVTRD ANNQITGFNS GLSCEILTQE GCAPVLVASW SYDGKYIVAG HQDGKISKYN
     GVTGECLEIK DLHKQRVSDI QFSLDRTYFL TTSRDSYANL VDVETFEVLK TYETDCPLNS
     GCITPLKEFV ILGGGQDARD VTTTSAREGK FEAKFYHKLF QVEIGRVDDH FGPVNYIAVS
     PQGTSYASGG EDGFVRLHHF DKSYFDFKFD VEKSADAQKK VDTADR