EIF3I_ASPCL
ID EIF3I_ASPCL Reviewed; 340 AA.
AC A1CJY4;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit I {ECO:0000255|HAMAP-Rule:MF_03008};
DE Short=eIF3i {ECO:0000255|HAMAP-Rule:MF_03008};
DE AltName: Full=Eukaryotic translation initiation factor 3 39 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03008};
DE Short=eIF-3 39 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03008};
GN Name=tif34; ORFNames=ACLA_036630;
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03008}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03008}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03008}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit I family. {ECO:0000255|HAMAP-
CC Rule:MF_03008}.
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DR EMBL; DS027056; EAW09458.1; -; Genomic_DNA.
DR RefSeq; XP_001270884.1; XM_001270883.1.
DR AlphaFoldDB; A1CJY4; -.
DR SMR; A1CJY4; -.
DR STRING; 5057.CADACLAP00003914; -.
DR PRIDE; A1CJY4; -.
DR EnsemblFungi; EAW09458; EAW09458; ACLA_036630.
DR GeneID; 4702980; -.
DR KEGG; act:ACLA_036630; -.
DR VEuPathDB; FungiDB:ACLA_036630; -.
DR eggNOG; KOG0643; Eukaryota.
DR HOGENOM; CLU_043845_0_1_1; -.
DR OMA; VWFSHNG; -.
DR OrthoDB; 866359at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0071540; C:eukaryotic translation initiation factor 3 complex, eIF3e; IEA:EnsemblFungi.
DR GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IEA:EnsemblFungi.
DR GO; GO:0034399; C:nuclear periphery; IEA:EnsemblFungi.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03008; eIF3i; 1.
DR InterPro; IPR027525; eIF3i.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW Repeat; WD repeat.
FT CHAIN 1..340
FT /note="Eukaryotic translation initiation factor 3 subunit
FT I"
FT /id="PRO_0000365355"
FT REPEAT 8..47
FT /note="WD 1"
FT REPEAT 50..91
FT /note="WD 2"
FT REPEAT 93..135
FT /note="WD 3"
FT REPEAT 150..189
FT /note="WD 4"
FT REPEAT 194..233
FT /note="WD 5"
FT REPEAT 291..330
FT /note="WD 6"
SQ SEQUENCE 340 AA; 37702 MW; 018AD3C7ECDAFC5D CRC64;
MRPILLSGHE RSLNQIKFNR DGDLLFSVSK DKVVCAWWSA NGERLGTYTG HQGAIWTVDV
SPNTVLLATG SADNTVRLWN VKTGECVKVW DFPTAVKRVA FSPDGSKLLA VTEKRMGFLG
TIAVFDINYG NGQGEDLENQ AEEPSLRITC SESKATVAGW SYLGKYIIAG HEDGSVSQYD
GKTGEQLENV QAHEFDHQIN DIQFSQDRTC FITASKDKSA KLISSRNLAI LKTYVADTPL
NSATITPKKD FVILGGGQAA MDVTTTSARQ GKFEARFYHK VFEDEIGRVK GHFGPLNTVD
VHPNGTAYAS GGEDGYVRVH HFDKPYFDFM YEVEREQLRK
