ID   AG19_COCIM              Reviewed;         146 AA.
AC   Q1E8D2; J3KIU2;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Heat-stable 19 kDa antigen;
DE   AltName: Full=CS-AG;
DE   Flags: Precursor;
GN   Name=CSA; ORFNames=CIMG_01181;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- PTM: Glycosylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cerato-platanin family. {ECO:0000305}.
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DR   EMBL; GG704911; EAS35827.3; -; Genomic_DNA.
DR   RefSeq; XP_001247410.1; XM_001247409.2.
DR   AlphaFoldDB; Q1E8D2; -.
DR   SMR; Q1E8D2; -.
DR   STRING; 246410.Q1E8D2; -.
DR   EnsemblFungi; EAS35827; EAS35827; CIMG_01181.
DR   GeneID; 4565522; -.
DR   KEGG; cim:CIMG_01181; -.
DR   VEuPathDB; FungiDB:CIMG_01181; -.
DR   InParanoid; Q1E8D2; -.
DR   OMA; CGTCWQV; -.
DR   OrthoDB; 1430841at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.40.40.10; -; 1.
DR   InterPro; IPR010829; Cerato-platanin.
DR   InterPro; IPR036908; RlpA-like_sf.
DR   Pfam; PF07249; Cerato-platanin; 1.
DR   SUPFAM; SSF50685; SSF50685; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..146
FT                   /note="Heat-stable 19 kDa antigen"
FT                   /id="PRO_0000252284"
SQ   SEQUENCE   146 AA;  15563 MW;  9F67BB710466D885 CRC64;
     MKFSLLSAIA AAVFVPFTSA TPLASTTDLS YDTHYDDPSL ALSGVTCSDG DNGMITKGYN
     TAGEIPNYPH VGGAFTVETW NSPNCGKCYK VTYNAKTIFL TAIDHSNSGF NIAKKSMDVL
     TNGRAEELGR IKVTYEEVAS SLCGLK