EIF3I_ASPTN
ID EIF3I_ASPTN Reviewed; 336 AA.
AC Q0CXH9;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 1.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit I {ECO:0000255|HAMAP-Rule:MF_03008};
DE Short=eIF3i {ECO:0000255|HAMAP-Rule:MF_03008};
DE AltName: Full=Eukaryotic translation initiation factor 3 39 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03008};
DE Short=eIF-3 39 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03008};
GN Name=tif34; ORFNames=ATEG_01605;
OS Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=341663;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIH 2624 / FGSC A1156;
RA Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA Nierman W.C., Milne T., Madden K.;
RT "Annotation of the Aspergillus terreus NIH2624 genome.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03008}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03008}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03008}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit I family. {ECO:0000255|HAMAP-
CC Rule:MF_03008}.
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DR EMBL; CH476595; EAU38362.1; -; Genomic_DNA.
DR RefSeq; XP_001208970.1; XM_001208970.1.
DR AlphaFoldDB; Q0CXH9; -.
DR SMR; Q0CXH9; -.
DR STRING; 341663.Q0CXH9; -.
DR EnsemblFungi; EAU38362; EAU38362; ATEG_01605.
DR GeneID; 4315575; -.
DR VEuPathDB; FungiDB:ATEG_01605; -.
DR eggNOG; KOG0643; Eukaryota.
DR HOGENOM; CLU_043845_0_1_1; -.
DR OMA; VWFSHNG; -.
DR OrthoDB; 866359at2759; -.
DR Proteomes; UP000007963; Unassembled WGS sequence.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0071540; C:eukaryotic translation initiation factor 3 complex, eIF3e; IEA:EnsemblFungi.
DR GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IEA:EnsemblFungi.
DR GO; GO:0034399; C:nuclear periphery; IEA:EnsemblFungi.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03008; eIF3i; 1.
DR InterPro; IPR027525; eIF3i.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW Repeat; WD repeat.
FT CHAIN 1..336
FT /note="Eukaryotic translation initiation factor 3 subunit
FT I"
FT /id="PRO_0000365360"
FT REPEAT 8..47
FT /note="WD 1"
FT REPEAT 50..91
FT /note="WD 2"
FT REPEAT 146..185
FT /note="WD 3"
FT REPEAT 190..229
FT /note="WD 4"
FT REPEAT 287..326
FT /note="WD 5"
SQ SEQUENCE 336 AA; 37438 MW; 1634F12D722A4E0B CRC64;
MRPILLSGHE RSLTQIKFNR DGDLLFSVSK DKIVCAWWTA NGERLGTYNG HLGAVWTVDV
SPNTVLLATG SADNSVRLWN VKTGECVKVW EFPTAVKRVE FSPDGSQLLA VTEKRMGFLG
AISVLDISYE DNFQNQADEP SLRITCNESK ATVAGWSYLG KYIIAGHEDG SVSQYDAKTG
DQLENVQAHE FDHQINDIQF SADRTYFITA SKDKSAKLIS SRNLAILKTY VADTPLNSAT
ITPKKDYVIL GGGQAAMDVT TTSARQGKFE ARFYHKVFED EIGRVRGHFG PLNTVGVHPN
GTAYASGGED GYVRVHHFDK PYFDFMYEVE REQMRK
