ID   EIF3I_CAEBR             Reviewed;         327 AA.
AC   A8WVX8;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit I {ECO:0000255|HAMAP-Rule:MF_03008};
DE            Short=eIF3i {ECO:0000255|HAMAP-Rule:MF_03008};
GN   Name=eif-3.I {ECO:0000255|HAMAP-Rule:MF_03008,
GN   ECO:0000312|WormBase:CBG03991};
GN   ORFNames=CBG03991 {ECO:0000312|WormBase:CBG03991};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03008}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03008}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03008}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit I family. {ECO:0000255|HAMAP-
CC       Rule:MF_03008}.
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DR   EMBL; HE600906; CAP24790.1; -; Genomic_DNA.
DR   RefSeq; XP_002639403.1; XM_002639357.1.
DR   AlphaFoldDB; A8WVX8; -.
DR   SMR; A8WVX8; -.
DR   STRING; 6238.CBG03991; -.
DR   EnsemblMetazoa; CBG03991.1; CBG03991.1; WBGene00026744.
DR   GeneID; 8581396; -.
DR   KEGG; cbr:CBG_03991; -.
DR   CTD; 8581396; -.
DR   WormBase; CBG03991; CBP06619; WBGene00026744; Cbr-eif-3.I.
DR   eggNOG; KOG0643; Eukaryota.
DR   HOGENOM; CLU_043845_0_1_1; -.
DR   InParanoid; A8WVX8; -.
DR   OMA; VWFSHNG; -.
DR   OrthoDB; 866359at2759; -.
DR   Proteomes; UP000008549; Chromosome I.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR   GO; GO:0002183; P:cytoplasmic translational initiation; IBA:GO_Central.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03008; eIF3i; 1.
DR   InterPro; IPR027525; eIF3i.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW   Repeat; WD repeat.
FT   CHAIN           1..327
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   I"
FT                   /id="PRO_0000365336"
FT   REPEAT          8..49
FT                   /note="WD 1"
FT   REPEAT          51..89
FT                   /note="WD 2"
FT   REPEAT          188..227
FT                   /note="WD 3"
FT   REPEAT          229..268
FT                   /note="WD 4"
FT   REPEAT          285..324
FT                   /note="WD 5"
SQ   SEQUENCE   327 AA;  36650 MW;  170BAD0EE8B430A6 CRC64;
     MRPLSLKGHE RALTRVRFNR EGDLTFSCAK DKKPCVWYTE NGERIGSYDG HNGAVWDIDV
     SWDTSKCVTA SGDLTVKIWD AELGSCIYTI NHQTPMKSCG FSYSGNLVCY TTQKMTKNLS
     TVQVRDLRDG NQMAEGAESF FSTQFDVNAT TALFSQMDDI ITIGFESGLL QQYDLRNPDS
     PINTNEVVHR YSIQDLQLSP RGDFLISASR DKTAALLDVN DLKKLKQYKS ERPVNSACIA
     PNRDHICLGG GEDAMQVTQT AVSAGHFEAK IYHMVFEEEF ARFKGHFGPI NTMAWHPSGS
     IIATGGEDGY VRIQEFDEDY LGFTYDF