EIF3I_CAEEL
ID EIF3I_CAEEL Reviewed; 327 AA.
AC Q965S8;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 2.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit I {ECO:0000255|HAMAP-Rule:MF_03008};
DE Short=eIF3i {ECO:0000255|HAMAP-Rule:MF_03008};
GN Name=eif-3.I {ECO:0000255|HAMAP-Rule:MF_03008};
GN ORFNames=Y74C10AR.1 {ECO:0000312|WormBase:Y74C10AR.1a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03008}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03008}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03008}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit I family. {ECO:0000255|HAMAP-
CC Rule:MF_03008}.
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DR EMBL; FO081786; CCD73538.1; -; Genomic_DNA.
DR RefSeq; NP_490988.2; NM_058587.4.
DR AlphaFoldDB; Q965S8; -.
DR SMR; Q965S8; -.
DR BioGRID; 37294; 16.
DR IntAct; Q965S8; 1.
DR STRING; 6239.Y74C10AR.1; -.
DR EPD; Q965S8; -.
DR PaxDb; Q965S8; -.
DR PeptideAtlas; Q965S8; -.
DR EnsemblMetazoa; Y74C10AR.1a.1; Y74C10AR.1a.1; WBGene00001232.
DR GeneID; 171809; -.
DR KEGG; cel:CELE_Y74C10AR.1; -.
DR UCSC; Y74C10AR.1; c. elegans.
DR CTD; 171809; -.
DR WormBase; Y74C10AR.1a; CE30325; WBGene00001232; eif-3.I.
DR eggNOG; KOG0643; Eukaryota.
DR GeneTree; ENSGT00940000167369; -.
DR HOGENOM; CLU_043845_0_1_1; -.
DR InParanoid; Q965S8; -.
DR OMA; VWFSHNG; -.
DR OrthoDB; 866359at2759; -.
DR PhylomeDB; Q965S8; -.
DR Reactome; R-CEL-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-CEL-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-CEL-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-CEL-72702; Ribosomal scanning and start codon recognition.
DR PRO; PR:Q965S8; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00001232; Expressed in adult organism and 4 other tissues.
DR ExpressionAtlas; Q965S8; baseline and differential.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003743; F:translation initiation factor activity; IBA:GO_Central.
DR GO; GO:0002183; P:cytoplasmic translational initiation; IBA:GO_Central.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03008; eIF3i; 1.
DR InterPro; IPR027525; eIF3i.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW Repeat; WD repeat.
FT CHAIN 1..327
FT /note="Eukaryotic translation initiation factor 3 subunit
FT I"
FT /id="PRO_0000365337"
FT REPEAT 8..49
FT /note="WD 1"
FT REPEAT 51..89
FT /note="WD 2"
FT REPEAT 188..227
FT /note="WD 3"
FT REPEAT 229..268
FT /note="WD 4"
FT REPEAT 285..324
FT /note="WD 5"
SQ SEQUENCE 327 AA; 36873 MW; BC30C4C154FD224C CRC64;
MRPLSLKGHE RALTRVRFNR EGDLTFSCAK DKKPCVWYTE NGERIGSYDG HNGAVWDIDV
SWDTTKCVTA SGDLTVKIWD AELGNCLYTI NHQTPMKSCG FSYSGNLVCF TTQKMTKNLS
TFQVRDLRDS SQMVEGGESF FYSQFDVNAT TALFTQMDDL VTIGFESGLL QQYDLRNPDT
PIHTNESVHR YSVQDLQLSP RGDFLISASR DKTAALLDVN DLKKLKQYKS ERPVNSACIS
PNRDHICLGG GEDAMQVTQT SVSAGHFEAK IYHMVFEEEF ARFKGHFGPI NTMAWHPSGT
IIATGGEDGY IRIQEFDEDY LGFTYDF
