ID   EIF3I_CHAGB             Reviewed;         341 AA.
AC   Q2GTM8;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit I {ECO:0000255|HAMAP-Rule:MF_03008};
DE            Short=eIF3i {ECO:0000255|HAMAP-Rule:MF_03008};
DE   AltName: Full=Eukaryotic translation initiation factor 3 39 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03008};
DE            Short=eIF-3 39 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03008};
GN   Name=TIF34 {ECO:0000255|HAMAP-Rule:MF_03008}; ORFNames=CHGG_08676;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03008}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03008}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03008}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit I family. {ECO:0000255|HAMAP-
CC       Rule:MF_03008}.
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DR   EMBL; CH408034; EAQ84662.1; -; Genomic_DNA.
DR   RefSeq; XP_001226603.1; XM_001226602.1.
DR   AlphaFoldDB; Q2GTM8; -.
DR   SMR; Q2GTM8; -.
DR   STRING; 38033.XP_001226603.1; -.
DR   EnsemblFungi; EAQ84662; EAQ84662; CHGG_08676.
DR   GeneID; 4395197; -.
DR   eggNOG; KOG0643; Eukaryota.
DR   HOGENOM; CLU_043845_0_1_1; -.
DR   InParanoid; Q2GTM8; -.
DR   OMA; VWFSHNG; -.
DR   OrthoDB; 866359at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03008; eIF3i; 1.
DR   InterPro; IPR027525; eIF3i.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 3.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW   Repeat; WD repeat.
FT   CHAIN           1..341
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   I"
FT                   /id="PRO_0000365363"
FT   REPEAT          8..49
FT                   /note="WD 1"
FT   REPEAT          50..91
FT                   /note="WD 2"
FT   REPEAT          135..184
FT                   /note="WD 3"
FT   REPEAT          189..228
FT                   /note="WD 4"
FT   REPEAT          286..325
FT                   /note="WD 5"
SQ   SEQUENCE   341 AA;  37841 MW;  EB61D6A274DA8F02 CRC64;
     MRPILLAGHE RALTQIKYNP DGDLIFSVSK DQQICVWFAH NGERLGTYRG HQGAIWTIDV
     DPTSTILASG SADNTIRLWD IKTGKCLKTW DFPTAVKRVE FNEDGTKLLG VTEKRMGHLG
     TIVVLDIKID VEAEQSDEKV MTIVCDESKA TVAGWSYLSK YIIAGHEDGS VSQYDGKTGD
     LLYNIPIHEL NQPITDLQWS QDRTYFITAS KDKTSKLISS KDLEVLKSYT ADTPLNSAAI
     TPKKDFVILG GGQAAMDVTT TAARQGKFEA RFYHKIFEDE IGRVRGHFGP LNTVAADPTG
     KGYASGGEDG YVRVHAFDKG YYDFLYEVER ERQNRLAAAS A