ID   AG19_COCP7              Reviewed;         146 AA.
AC   P0CW95; C5PH30; Q00398; Q8J1X8;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   31-MAY-2011, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Heat-stable 19 kDa antigen;
DE   AltName: Full=Coccidioides-specific antigen;
DE            Short=CS antigen;
DE            Short=CS-AG;
DE   AltName: Full=Precipitin antigen;
DE   AltName: Full=TP-AG;
DE   Flags: Precursor;
GN   Name=CSA; Synonyms=CAG; ORFNames=CPC735_052030;
OS   Coccidioides posadasii (strain C735) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=222929;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 24-79 AND
RP   81-100.
RC   STRAIN=C735;
RX   PubMed=7558310; DOI=10.1128/iai.63.10.3994-4002.1995;
RA   Pan S., Cole G.T.;
RT   "Molecular and biochemical characterization of a Coccidioides immitis-
RT   specific antigen.";
RL   Infect. Immun. 63:3994-4002(1995).
RN   [2]
RP   SEQUENCE REVISION, AND IDENTIFICATION OF FRAMESHIFT.
RC   STRAIN=C735;
RA   Cole G.T., Yu J.-J., Pan S.;
RT   "Molecular characterization of the Coccidioides-specific antigen.";
RL   Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C735;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: Glycosylated.
CC   -!- SIMILARITY: Belongs to the cerato-platanin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB00101.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; L36551; AAB00101.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; AY158466; AAN73410.1; -; Genomic_DNA.
DR   EMBL; ACFW01000049; EER23833.1; -; Genomic_DNA.
DR   RefSeq; XP_003065978.1; XM_003065932.1.
DR   AlphaFoldDB; P0CW95; -.
DR   SMR; P0CW95; -.
DR   EnsemblFungi; EER23833; EER23833; CPC735_052030.
DR   GeneID; 9691448; -.
DR   KEGG; cpw:CPC735_052030; -.
DR   VEuPathDB; FungiDB:CPC735_052030; -.
DR   HOGENOM; CLU_111635_0_0_1; -.
DR   Proteomes; UP000009084; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.40.40.10; -; 1.
DR   InterPro; IPR010829; Cerato-platanin.
DR   InterPro; IPR036908; RlpA-like_sf.
DR   Pfam; PF07249; Cerato-platanin; 1.
DR   SUPFAM; SSF50685; SSF50685; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Glycoprotein; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..146
FT                   /note="Heat-stable 19 kDa antigen"
FT                   /id="PRO_0000004999"
SQ   SEQUENCE   146 AA;  15559 MW;  1416EA20416789DB CRC64;
     MKFSLLSAIA AAVFVPFTSA TPLASTADLS YDTHYDDPSL PLSGVTCSDG DNGMITKGYN
     TAGEIPNYPH VGGAFTVETW NSPNCGKCYK VTYNAKTIFL TAIDHSNSGF NIAKKSMDVL
     TNGRAEELGR IKVTYEEVAS SLCGLK