ID   EIF3I_CULQU             Reviewed;         328 AA.
AC   B0XFT7;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit I {ECO:0000255|HAMAP-Rule:MF_03008};
DE            Short=eIF3i {ECO:0000255|HAMAP-Rule:MF_03008};
GN   ORFNames=CPIJ018275, CPIJ018457;
OS   Culex quinquefasciatus (Southern house mosquito) (Culex pungens).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Culicini; Culex; Culex.
OX   NCBI_TaxID=7176;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JHB;
RG   The Broad Institute Genome Sequencing Platform;
RA   Atkinson P.W., Hemingway J., Christensen B.M., Higgs S., Kodira C.D.,
RA   Hannick L.I., Megy K., O'Leary S.B., Pearson M., Haas B.J., Mauceli E.,
RA   Wortman J.R., Lee N.H., Guigo R., Stanke M., Alvarado L., Amedeo P.,
RA   Antoine C.H., Arensburger P., Bidwell S.L., Crawford M., Camaro F.,
RA   Devon K., Engels R., Hammond M., Howarth C., Koehrsen M., Lawson D.,
RA   Montgomery P., Nene V., Nusbaum C., Puiu D., Romero-Severson J.,
RA   Severson D.W., Shumway M., Sisk P., Stolte C., Zeng Q., Eisenstadt E.,
RA   Fraser-Liggett C.M., Strausberg R., Galagan J., Birren B., Collins F.H.;
RT   "Annotation of Culex pipiens quinquefasciatus.";
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03008}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03008}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03008}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit I family. {ECO:0000255|HAMAP-
CC       Rule:MF_03008}.
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DR   EMBL; DS232960; EDS27016.1; -; Genomic_DNA.
DR   EMBL; DS233035; EDS27653.1; -; Genomic_DNA.
DR   RefSeq; XP_001868509.1; XM_001868474.1.
DR   RefSeq; XP_001868761.1; XM_001868726.1.
DR   AlphaFoldDB; B0XFT7; -.
DR   SMR; B0XFT7; -.
DR   STRING; 7176.CPIJ018275-PA; -.
DR   EnsemblMetazoa; XM_001868726.2; XP_001868761.1; LOC6052506.
DR   GeneID; 6052506; -.
DR   KEGG; cqu:CpipJ_CPIJ018275; -.
DR   KEGG; cqu:CpipJ_CPIJ018457; -.
DR   VEuPathDB; VectorBase:CPIJ018275; -.
DR   VEuPathDB; VectorBase:CPIJ018457; -.
DR   VEuPathDB; VectorBase:CQUJHB007268; -.
DR   eggNOG; KOG0643; Eukaryota.
DR   HOGENOM; CLU_043845_0_1_1; -.
DR   InParanoid; B0XFT7; -.
DR   OMA; VWFSHNG; -.
DR   OrthoDB; 866359at2759; -.
DR   PhylomeDB; B0XFT7; -.
DR   Proteomes; UP000002320; Partially assembled WGS sequence.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03008; eIF3i; 1.
DR   InterPro; IPR027525; eIF3i.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 4.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW   Repeat; WD repeat.
FT   CHAIN           1..328
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   I"
FT                   /id="PRO_0000365341"
FT   REPEAT          8..47
FT                   /note="WD 1"
FT   REPEAT          50..91
FT                   /note="WD 2"
FT   REPEAT          148..187
FT                   /note="WD 3"
FT   REPEAT          190..229
FT                   /note="WD 4"
FT   REPEAT          287..328
FT                   /note="WD 5"
SQ   SEQUENCE   328 AA;  36114 MW;  91050B9825E9869A CRC64;
     MKPLMLQGHE RAITQIKYNR EGDLIFSTAK DHKPSVWFSL NGERLGTYNG HQGAVWCVDV
     DWTTTRLITG AGDMSTKLWD VETGSVLGTI PCNSAARTAN FSFSGNQASY STDKAMGHNS
     ELFIIDVRNV DSSISSQSPV LKLTMNQSIQ TKITSMLWGA LDETVITGHE NGSIRIWDLR
     TAKELNSVND HTGVINDMQL SADGTMLVSA SKDTTAKLFD SESLMCLKTY KTERPVNSAA
     ISPIHEHVVL GGGQEAMEVT TTSTKSGKFD SRLFHLVYEE EFARVKGHFG PINSLAFHPD
     GKSYATGGED GFVRVQVFDA SYYEFVFE