EIF3I_DANRE
ID EIF3I_DANRE Reviewed; 325 AA.
AC Q7ZV55;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit I {ECO:0000255|HAMAP-Rule:MF_03008};
DE Short=eIF3i {ECO:0000255|HAMAP-Rule:MF_03008};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 2 {ECO:0000255|HAMAP-Rule:MF_03008};
DE AltName: Full=eIF-3-beta {ECO:0000255|HAMAP-Rule:MF_03008};
DE AltName: Full=eIF3 p36 {ECO:0000255|HAMAP-Rule:MF_03008};
GN Name=eif3i; Synonyms=eif3s2;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03008}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c,
CC eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and
CC eif3m. {ECO:0000255|HAMAP-Rule:MF_03008}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03008}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit I family. {ECO:0000255|HAMAP-
CC Rule:MF_03008}.
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DR EMBL; BC045995; AAH45995.1; -; mRNA.
DR EMBL; BC065874; AAH65874.1; -; mRNA.
DR RefSeq; NP_998155.1; NM_212990.1.
DR AlphaFoldDB; Q7ZV55; -.
DR SMR; Q7ZV55; -.
DR STRING; 7955.ENSDARP00000017792; -.
DR PaxDb; Q7ZV55; -.
DR PRIDE; Q7ZV55; -.
DR Ensembl; ENSDART00000005119; ENSDARP00000017792; ENSDARG00000017445.
DR GeneID; 406263; -.
DR KEGG; dre:406263; -.
DR CTD; 8668; -.
DR ZFIN; ZDB-GENE-040426-1922; eif3i.
DR eggNOG; KOG0643; Eukaryota.
DR GeneTree; ENSGT00940000161371; -.
DR HOGENOM; CLU_043845_0_1_1; -.
DR InParanoid; Q7ZV55; -.
DR OMA; VWFSHNG; -.
DR OrthoDB; 866359at2759; -.
DR PhylomeDB; Q7ZV55; -.
DR TreeFam; TF101515; -.
DR Reactome; R-DRE-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-DRE-72649; Translation initiation complex formation.
DR Reactome; R-DRE-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-DRE-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-DRE-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-DRE-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR PRO; PR:Q7ZV55; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 19.
DR Bgee; ENSDARG00000017445; Expressed in pharyngeal gill and 39 other tissues.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:UniProtKB.
DR GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003743; F:translation initiation factor activity; ISS:UniProtKB.
DR GO; GO:0002183; P:cytoplasmic translational initiation; IBA:GO_Central.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0001889; P:liver development; IMP:ZFIN.
DR GO; GO:0002040; P:sprouting angiogenesis; IMP:ZFIN.
DR GO; GO:0006413; P:translational initiation; ISS:UniProtKB.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03008; eIF3i; 1.
DR InterPro; IPR027525; eIF3i.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 2: Evidence at transcript level;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW Repeat; WD repeat.
FT CHAIN 1..325
FT /note="Eukaryotic translation initiation factor 3 subunit
FT I"
FT /id="PRO_0000365332"
FT REPEAT 8..47
FT /note="WD 1"
FT REPEAT 50..89
FT /note="WD 2"
FT REPEAT 144..183
FT /note="WD 3"
FT REPEAT 186..225
FT /note="WD 4"
FT REPEAT 283..324
FT /note="WD 5"
SQ SEQUENCE 325 AA; 36287 MW; 062AC36D640CB585 CRC64;
MKPILLQGHE RSITQIKYNR EGDLLFSVAK DPIANVWYSV NGERLGTYNG HTGAVWCVDV
DWDTKNVLTG SADNSCRLWD CETGKQLALL ETSSAVRTCG FDFSGNIIMF STDKQMGYQC
FLNYYDLRDP QQIEDNQPYI SVPCSESKIT SAVWGPLGEF VIAGHENGEI NQFSAKSGEV
LKKAKEHTKQ INDIQSSVDL TMIISASKDC TAKMFDSSTL EHVKTFKTER PVNSAAISPI
MDHVVMGGGQ EAMEVTTTST RIGKFEARFF HAAYEEEFGR VKGHFGPINC VAFHPDGKSY
SSGGEDGYVR IHYFDPHYFD FELEA
