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EIF3I_DROER
ID   EIF3I_DROER             Reviewed;         326 AA.
AC   B3N4C7;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit I {ECO:0000255|HAMAP-Rule:MF_03008};
DE            Short=eIF3i {ECO:0000255|HAMAP-Rule:MF_03008};
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit 2 {ECO:0000255|HAMAP-Rule:MF_03008};
DE   AltName: Full=TRIP-1 homolog;
GN   Name=eIF3i {ECO:0000255|HAMAP-Rule:MF_03008};
GN   Synonyms=eif3-S2 {ECO:0000255|HAMAP-Rule:MF_03008},
GN   Trip1 {ECO:0000255|HAMAP-Rule:MF_03008}; ORFNames=GG24335;
OS   Drosophila erecta (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7220;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14021-0224.01;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03008}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. The eIF-3 complex interacts with pix.
CC       {ECO:0000255|HAMAP-Rule:MF_03008}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03008}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit I family. {ECO:0000255|HAMAP-
CC       Rule:MF_03008}.
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DR   EMBL; CH954177; EDV57797.1; -; Genomic_DNA.
DR   RefSeq; XP_001968738.1; XM_001968702.2.
DR   AlphaFoldDB; B3N4C7; -.
DR   SMR; B3N4C7; -.
DR   STRING; 7220.FBpp0142881; -.
DR   EnsemblMetazoa; FBtr0144389; FBpp0142881; FBgn0116467.
DR   GeneID; 6540828; -.
DR   KEGG; der:6540828; -.
DR   eggNOG; KOG0643; Eukaryota.
DR   HOGENOM; CLU_043845_0_1_1; -.
DR   OMA; VWFSHNG; -.
DR   OrthoDB; 866359at2759; -.
DR   PhylomeDB; B3N4C7; -.
DR   ChiTaRS; Trip1; fly.
DR   Proteomes; UP000008711; Unassembled WGS sequence.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03008; eIF3i; 1.
DR   InterPro; IPR027525; eIF3i.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 4.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Repeat; WD repeat.
FT   CHAIN           1..326
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   I"
FT                   /id="PRO_0000365343"
FT   REPEAT          8..47
FT                   /note="WD 1"
FT   REPEAT          50..89
FT                   /note="WD 2"
FT   REPEAT          145..184
FT                   /note="WD 3"
FT   REPEAT          188..227
FT                   /note="WD 4"
FT   REPEAT          285..326
FT                   /note="WD 5"
SQ   SEQUENCE   326 AA;  36190 MW;  B07D30F8E47F3641 CRC64;
     MRPLMLQGHE RSITQIKYNR EGDLLFSCSK DQKPNVWYSL NGERLGTYDG HQGAVWCLDV
     DWESRKLITG AGDMTTKIWD VEYGTVIASI PTKSSVRTSN FSFSGNQAAY STDKAMGQSC
     ELFLIDVRNA DSSLSEQEPT LRIPMTESKI TSMLWGPLDE TIITGHDNGN IAIWDIRKGQ
     KVVDSGTDHS AGINDMQLSK DGTMFVTASK DTTAKLFDSE SLMCLKTYKT ERPVNSAAIS
     PIMDHVVLGG GQDAMEVTTT STKAGKFDSR FFHLIYEEEF ARLKGHFGPI NSLAFHPDGK
     SYASGGEDGF VRVQTFDSTY FENIFE
 
 
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