EIF3I_DROGR
ID EIF3I_DROGR Reviewed; 326 AA.
AC B4JB43;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit I {ECO:0000255|HAMAP-Rule:MF_03008};
DE Short=eIF3i {ECO:0000255|HAMAP-Rule:MF_03008};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 2 {ECO:0000255|HAMAP-Rule:MF_03008};
DE AltName: Full=TRIP-1 homolog;
GN Name=eIF3i {ECO:0000255|HAMAP-Rule:MF_03008};
GN Synonyms=eif3-S2 {ECO:0000255|HAMAP-Rule:MF_03008},
GN Trip1 {ECO:0000255|HAMAP-Rule:MF_03008}; ORFNames=GH10244;
OS Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Hawaiian Drosophila.
OX NCBI_TaxID=7222;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15287-2541.00;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03008}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. The eIF-3 complex interacts with pix.
CC {ECO:0000255|HAMAP-Rule:MF_03008}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03008}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit I family. {ECO:0000255|HAMAP-
CC Rule:MF_03008}.
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DR EMBL; CH916368; EDW03935.1; -; Genomic_DNA.
DR RefSeq; XP_001989068.1; XM_001989032.1.
DR AlphaFoldDB; B4JB43; -.
DR SMR; B4JB43; -.
DR STRING; 7222.FBpp0144150; -.
DR EnsemblMetazoa; FBtr0145658; FBpp0144150; FBgn0117725.
DR GeneID; 6562758; -.
DR KEGG; dgr:6562758; -.
DR eggNOG; KOG0643; Eukaryota.
DR HOGENOM; CLU_043845_0_1_1; -.
DR InParanoid; B4JB43; -.
DR OMA; VWFSHNG; -.
DR OrthoDB; 866359at2759; -.
DR PhylomeDB; B4JB43; -.
DR ChiTaRS; Trip1; fly.
DR Proteomes; UP000001070; Unassembled WGS sequence.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03008; eIF3i; 1.
DR InterPro; IPR027525; eIF3i.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW Repeat; WD repeat.
FT CHAIN 1..326
FT /note="Eukaryotic translation initiation factor 3 subunit
FT I"
FT /id="PRO_0000365344"
FT REPEAT 8..47
FT /note="WD 1"
FT REPEAT 50..89
FT /note="WD 2"
FT REPEAT 145..184
FT /note="WD 3"
FT REPEAT 188..227
FT /note="WD 4"
FT REPEAT 285..326
FT /note="WD 5"
SQ SEQUENCE 326 AA; 36168 MW; 580ADD759758DD16 CRC64;
MRPLMLQGHE RSITQIKYNR EGDLLFSSSK DQKPNVWYSL NGERLGTYDG HQGAVWCLDV
DWESRKLITG AGDMTTKLWD VEYGTVIASI ATKSSVRTSN FSFSGNQAAY STDKAMGQNC
ELFIIDVRNA DSTLSEQEPT LRIPMVESKI TSMQWGPLDE TIITGHDNGN IAIWDVRKGQ
KVVDSGVDHA AGINDMQLSK DGTMFVTASK DNTAKLFDAE SLMCLKTYKT ERPVNSAAIS
PIFDHVVLGG GQDAMEVTTT STKAGKFDSR FFHLIYEEEF ARLKGHFGPI NSLAFHPDGK
SYASGGEDGF VRVQSFDSTY FENIFE
