ID   AG19_COCPS              Reviewed;         146 AA.
AC   E9CX44; C5PH30; Q00398; Q8J1X8;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-APR-2011, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Heat-stable 19 kDa antigen;
DE   AltName: Full=Coccidioides-specific antigen;
DE            Short=CS antigen;
DE            Short=CS-AG;
DE   AltName: Full=Precipitin antigen;
DE   AltName: Full=TP-AG;
DE   Flags: Precursor;
GN   Name=CSA; Synonyms=CAG; ORFNames=CPSG_02027;
OS   Coccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=443226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RMSCC 757 / Silveira;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Neafsey D., Orbach M., Henn M.R., Cole G.T., Galgiani J., Gardner M.J.,
RA   Kirkland T.N., Taylor J.W., Young S.K., Zeng Q., Koehrsen M., Alvarado L.,
RA   Berlin A., Borenstein D., Chapman S.B., Chen Z., Engels R., Freedman E.,
RA   Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D.,
RA   Howarth C., Jen D., Larson L., Mehta T., Neiman D., Park D., Pearson M.,
RA   Richards J., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C.,
RA   Sykes S., Walk T., White J., Yandava C., Haas B., Nusbaum C., Birren B.;
RT   "The genome sequence of Coccidioides posadasii strain Silveira.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PROTEIN SEQUENCE OF 21-46.
RC   STRAIN=RMSCC 757 / Silveira;
RX   PubMed=2312685; DOI=10.1128/jcm.28.2.385-388.1990;
RA   Resnick S., Zimmer B., Pappagianis D., Eakin A., McKerrow J.;
RT   "Purification and amino-terminal sequence analysis of the complement-fixing
RT   and precipitin antigens from Coccidioides immitis.";
RL   J. Clin. Microbiol. 28:385-388(1990).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: Glycosylated.
CC   -!- SIMILARITY: Belongs to the cerato-platanin family. {ECO:0000305}.
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DR   EMBL; GL636487; EFW21870.1; -; Genomic_DNA.
DR   AlphaFoldDB; E9CX44; -.
DR   SMR; E9CX44; -.
DR   STRING; 443226.E9CX44; -.
DR   EnsemblFungi; EFW21870; EFW21870; CPSG_02027.
DR   VEuPathDB; FungiDB:CPSG_02027; -.
DR   eggNOG; ENOG502SQTH; Eukaryota.
DR   HOGENOM; CLU_111635_0_0_1; -.
DR   Proteomes; UP000002497; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.40.40.10; -; 1.
DR   InterPro; IPR010829; Cerato-platanin.
DR   InterPro; IPR036908; RlpA-like_sf.
DR   Pfam; PF07249; Cerato-platanin; 1.
DR   SUPFAM; SSF50685; SSF50685; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Glycoprotein; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..146
FT                   /note="Heat-stable 19 kDa antigen"
FT                   /id="PRO_0000409489"
SQ   SEQUENCE   146 AA;  15559 MW;  1416EA20416789DB CRC64;
     MKFSLLSAIA AAVFVPFTSA TPLASTADLS YDTHYDDPSL PLSGVTCSDG DNGMITKGYN
     TAGEIPNYPH VGGAFTVETW NSPNCGKCYK VTYNAKTIFL TAIDHSNSGF NIAKKSMDVL
     TNGRAEELGR IKVTYEEVAS SLCGLK