EIF3I_DROMO
ID EIF3I_DROMO Reviewed; 322 AA.
AC B4KGX9;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit I {ECO:0000255|HAMAP-Rule:MF_03008};
DE Short=eIF3i {ECO:0000255|HAMAP-Rule:MF_03008};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 2 {ECO:0000255|HAMAP-Rule:MF_03008};
DE AltName: Full=TRIP-1 homolog;
GN Name=eIF3i {ECO:0000255|HAMAP-Rule:MF_03008};
GN Synonyms=eif3-S2 {ECO:0000255|HAMAP-Rule:MF_03008},
GN Trip1 {ECO:0000255|HAMAP-Rule:MF_03008}; ORFNames=GI15375;
OS Drosophila mojavensis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7230;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15081-1352.22;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03008}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. The eIF-3 complex interacts with pix.
CC {ECO:0000255|HAMAP-Rule:MF_03008}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03008}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit I family. {ECO:0000255|HAMAP-
CC Rule:MF_03008}.
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DR EMBL; CH933807; EDW11179.1; -; Genomic_DNA.
DR RefSeq; XP_002001737.2; XM_002001701.2.
DR AlphaFoldDB; B4KGX9; -.
DR SMR; B4KGX9; -.
DR STRING; 7230.FBpp0164592; -.
DR EnsemblMetazoa; FBtr0166100; FBpp0164592; FBgn0138124.
DR GeneID; 6575732; -.
DR KEGG; dmo:Dmoj_GI15375; -.
DR eggNOG; KOG0643; Eukaryota.
DR HOGENOM; CLU_043845_0_1_1; -.
DR InParanoid; B4KGX9; -.
DR OMA; VWFSHNG; -.
DR OrthoDB; 866359at2759; -.
DR PhylomeDB; B4KGX9; -.
DR ChiTaRS; Trip1; fly.
DR Proteomes; UP000009192; Unassembled WGS sequence.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03008; eIF3i; 1.
DR InterPro; IPR027525; eIF3i.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW Repeat; WD repeat.
FT CHAIN 1..322
FT /note="Eukaryotic translation initiation factor 3 subunit
FT I"
FT /id="PRO_0000365345"
FT REPEAT 4..43
FT /note="WD 1"
FT REPEAT 46..85
FT /note="WD 2"
FT REPEAT 141..180
FT /note="WD 3"
FT REPEAT 184..223
FT /note="WD 4"
FT REPEAT 281..322
FT /note="WD 5"
SQ SEQUENCE 322 AA; 35615 MW; 422D372D1D126C75 CRC64;
MLQGHERSIT QIKYNREGDL LFSCSKDQKP NVWYSLNGER LGTYDGHQGA VWCLDVDWET
RKLITGAGDM TTKIWDVEYG TVIASIAAKS SVRTCNFSFS GNQAAYSTDK AMGQNCELFI
IDVRNADSSL SEQAPTLRIP MVESKITSML WGPLDETIIT GHDNGNIAIW DIRKGQKVVD
SGSDHTAGIN DMQLSKDGTM FVTASKDTTA KLFDSESLMC LKTYKTERPV NSAAISPILD
HVVLGGGQDA MEVTTTSTKA GKFDSRFFHL IYEEEFARLK GHFGPINSLA FHPDGKSYAS
GGEDGFVRVQ TFDSTYFENI FE
