EIF3I_DROPE
ID EIF3I_DROPE Reviewed; 326 AA.
AC B4GSH1;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 25-MAY-2022, entry version 64.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit I {ECO:0000255|HAMAP-Rule:MF_03008};
DE Short=eIF3i {ECO:0000255|HAMAP-Rule:MF_03008};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 2 {ECO:0000255|HAMAP-Rule:MF_03008};
DE AltName: Full=TRIP-1 homolog;
GN Name=eIF3i {ECO:0000255|HAMAP-Rule:MF_03008};
GN Synonyms=eif3-S2 {ECO:0000255|HAMAP-Rule:MF_03008},
GN Trip1 {ECO:0000255|HAMAP-Rule:MF_03008}; ORFNames=GL26537;
OS Drosophila persimilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7234;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MSH-3 / Tucson 14011-0111.49;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03008}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. The eIF-3 complex interacts with pix.
CC {ECO:0000255|HAMAP-Rule:MF_03008}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03008}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit I family. {ECO:0000255|HAMAP-
CC Rule:MF_03008}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CH479189; EDW25330.1; -; Genomic_DNA.
DR RefSeq; XP_002021487.1; XM_002021451.1.
DR AlphaFoldDB; B4GSH1; -.
DR SMR; B4GSH1; -.
DR STRING; 7234.FBpp0190644; -.
DR EnsemblMetazoa; FBtr0192152; FBpp0190644; FBgn0164119.
DR GeneID; 6596349; -.
DR KEGG; dpe:6596349; -.
DR eggNOG; KOG0643; Eukaryota.
DR HOGENOM; CLU_043845_0_1_1; -.
DR OMA; VWFSHNG; -.
DR PhylomeDB; B4GSH1; -.
DR ChiTaRS; Trip1; fly.
DR Proteomes; UP000008744; Unassembled WGS sequence.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03008; eIF3i; 1.
DR InterPro; IPR027525; eIF3i.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 5.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW Repeat; WD repeat.
FT CHAIN 1..326
FT /note="Eukaryotic translation initiation factor 3 subunit
FT I"
FT /id="PRO_0000365346"
FT REPEAT 8..47
FT /note="WD 1"
FT REPEAT 50..89
FT /note="WD 2"
FT REPEAT 145..184
FT /note="WD 3"
FT REPEAT 188..227
FT /note="WD 4"
FT REPEAT 285..326
FT /note="WD 5"
SQ SEQUENCE 326 AA; 36167 MW; 4F13606F674A65C7 CRC64;
MRPLMLQGHE RSITQIKYNR EGDLLFSCSK DQKPNVWYSL NGERLGTYDG HQGAVWCLDV
DWESRKLITG AGDMTTKLWD VEYGTIIASI PTKSSVRTSN FSFSGNQAAY STDKAMGQNC
ELFIIDVRNA DSTLADQTPT LRIPMTESKI TSMQWGPLDE TIITGHDNGN IAIWDVRKGQ
KVVDSGSDHA AGINDMQLSK DGTMFVTASR DTTAKLFDSE SLMCLKTYKT ERPVNSAAIS
PILDHVVLGG GQDAMEVTTT STKAGKFDSR FFHLIYEEEF ARLKGHFGPI NSLAFHPDGK
SYASGGEDGF VRVQTFDSTY FENIFE
