EIF3I_DROVI
ID EIF3I_DROVI Reviewed; 322 AA.
AC B4LUA5;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 2.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit I {ECO:0000255|HAMAP-Rule:MF_03008};
DE Short=eIF3i {ECO:0000255|HAMAP-Rule:MF_03008};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 2 {ECO:0000255|HAMAP-Rule:MF_03008};
DE AltName: Full=TRIP-1 homolog;
GN Name=eIF3i {ECO:0000255|HAMAP-Rule:MF_03008};
GN Synonyms=eif3-S2 {ECO:0000255|HAMAP-Rule:MF_03008},
GN Trip1 {ECO:0000255|HAMAP-Rule:MF_03008}; ORFNames=GJ17275;
OS Drosophila virilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7244;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15010-1051.87;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03008}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. The eIF-3 complex interacts with pix.
CC {ECO:0000255|HAMAP-Rule:MF_03008}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03008}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit I family. {ECO:0000255|HAMAP-
CC Rule:MF_03008}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EDW64092.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; CH940649; EDW64092.1; ALT_INIT; Genomic_DNA.
DR RefSeq; XP_002051937.2; XM_002051901.2.
DR AlphaFoldDB; B4LUA5; -.
DR SMR; B4LUA5; -.
DR STRING; 7244.FBpp0231692; -.
DR EnsemblMetazoa; FBtr0233200; FBpp0231692; FBgn0204451.
DR GeneID; 6629217; -.
DR KEGG; dvi:6629217; -.
DR eggNOG; KOG0643; Eukaryota.
DR InParanoid; B4LUA5; -.
DR OrthoDB; 866359at2759; -.
DR ChiTaRS; Trip1; fly.
DR Proteomes; UP000008792; Unassembled WGS sequence.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03008; eIF3i; 1.
DR InterPro; IPR027525; eIF3i.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW Repeat; WD repeat.
FT CHAIN 1..322
FT /note="Eukaryotic translation initiation factor 3 subunit
FT I"
FT /id="PRO_0000365350"
FT REPEAT 4..43
FT /note="WD 1"
FT REPEAT 46..85
FT /note="WD 2"
FT REPEAT 141..180
FT /note="WD 3"
FT REPEAT 184..223
FT /note="WD 4"
FT REPEAT 281..322
FT /note="WD 5"
SQ SEQUENCE 322 AA; 35711 MW; A4AFF493CCD5AE12 CRC64;
MLQGHERSIT QIKYNREGDL LFSSSKDQKP NVWYSLNGER LGTYDGHQGA VWCLDVDWES
RKLITGAGDM TTKIWDVEYG TVIASIPTKS SVRTSNFSFS GNQAAYSTDK AMGQNCELFI
IDVRNADSSL SEQEPTLRIP MVESKITSML WGPLDETIIT GHDNGNIAIW DIRKGQKVVD
SGTDHTAGIN DMQLSKDGTM FVTASRDTTA KLFDSESLMC LKTYKTERPV NSAAISPILD
HVVLGGGQDA MEVTTTSTKA GKFDSRFFHL IYEEEFARLK GHFGPINSLA FHPDGKSYAS
GGEDGFVRVQ SFDSTYFENI FE
