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EIF3I_DROWI
ID   EIF3I_DROWI             Reviewed;         322 AA.
AC   B4N0L0;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit I {ECO:0000255|HAMAP-Rule:MF_03008};
DE            Short=eIF3i {ECO:0000255|HAMAP-Rule:MF_03008};
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit 2 {ECO:0000255|HAMAP-Rule:MF_03008};
DE   AltName: Full=TRIP-1 homolog;
GN   Name=eIF3i {ECO:0000255|HAMAP-Rule:MF_03008};
GN   Synonyms=eif3-S2 {ECO:0000255|HAMAP-Rule:MF_03008},
GN   Trip1 {ECO:0000255|HAMAP-Rule:MF_03008}; ORFNames=GK24461;
OS   Drosophila willistoni (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7260;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14030-0811.24;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03008}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. The eIF-3 complex interacts with pix.
CC       {ECO:0000255|HAMAP-Rule:MF_03008}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03008}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit I family. {ECO:0000255|HAMAP-
CC       Rule:MF_03008}.
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DR   EMBL; CH963920; EDW77623.1; -; Genomic_DNA.
DR   RefSeq; XP_002066637.2; XM_002066601.2.
DR   AlphaFoldDB; B4N0L0; -.
DR   SMR; B4N0L0; -.
DR   STRING; 7260.FBpp0253604; -.
DR   EnsemblMetazoa; FBtr0255112; FBpp0253604; FBgn0226421.
DR   GeneID; 6644034; -.
DR   KEGG; dwi:6644034; -.
DR   eggNOG; KOG0643; Eukaryota.
DR   HOGENOM; CLU_043845_0_1_1; -.
DR   InParanoid; B4N0L0; -.
DR   OMA; VWFSHNG; -.
DR   OrthoDB; 866359at2759; -.
DR   PhylomeDB; B4N0L0; -.
DR   ChiTaRS; Trip1; fly.
DR   Proteomes; UP000007798; Unassembled WGS sequence.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03008; eIF3i; 1.
DR   InterPro; IPR027525; eIF3i.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 4.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW   Repeat; WD repeat.
FT   CHAIN           1..322
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   I"
FT                   /id="PRO_0000365351"
FT   REPEAT          4..43
FT                   /note="WD 1"
FT   REPEAT          46..85
FT                   /note="WD 2"
FT   REPEAT          141..180
FT                   /note="WD 3"
FT   REPEAT          184..223
FT                   /note="WD 4"
FT   REPEAT          281..322
FT                   /note="WD 5"
SQ   SEQUENCE   322 AA;  35658 MW;  0E01AC6DB1107EF6 CRC64;
     MLQGHERSIT QIKYNREGDL LFSSSKDQKP NVWYSLNGER LGTYDGHQGA VWCLDVDWES
     RKLITAGGDM TAKLWDVEYG TVIASIPTKS SVRTCNFSFS GNQAAYSTDK TMGQSCELFI
     IDVRNADSTL SEQTPTLRIP MTESKITSML WGPLDETIIT GHDNGNIAIW DVRKGQKVVD
     SGTDHTGVIN DMQLSKDGTM FVTASKDATA KLFDSETLMC LKTYKTERPV NSAAISPILD
     HVVLGGGQDA MEVTTTSTKA GKFDSRFFHL IYEEEFARLK GHFGPINSLA FHPDGKSYAS
     GGEDGFVRVQ SFDSTYFENI FE
 
 
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