ID   AG1L2_HUMAN             Reviewed;         215 AA.
AC   C9J202;
DT   18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Putative glycosyltransferase ALG1L2;
DE            EC=2.4.1.-;
GN   Name=ALG1L2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA   Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA   Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA   Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA   Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA   Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA   Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA   Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA   Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA   Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA   Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA   Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA   Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA   Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA   Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
CC   -!- FUNCTION: Putative glycosyltransferase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase group 1 family.
CC       {ECO:0000305}.
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DR   EMBL; AC083906; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001129624.1; NM_001136152.1.
DR   AlphaFoldDB; C9J202; -.
DR   SMR; C9J202; -.
DR   STRING; 9606.ENSP00000479850; -.
DR   iPTMnet; C9J202; -.
DR   PhosphoSitePlus; C9J202; -.
DR   BioMuta; ALG1L2; -.
DR   jPOST; C9J202; -.
DR   MassIVE; C9J202; -.
DR   MaxQB; C9J202; -.
DR   PeptideAtlas; C9J202; -.
DR   PRIDE; C9J202; -.
DR   ProteomicsDB; 8145; -.
DR   Antibodypedia; 77419; 3 antibodies from 3 providers.
DR   DNASU; 644974; -.
DR   Ensembl; ENST00000425059.1; ENSP00000479850.1; ENSG00000251287.8.
DR   GeneID; 644974; -.
DR   KEGG; hsa:644974; -.
DR   MANE-Select; ENST00000425059.1; ENSP00000479850.1; NM_001136152.1; NP_001129624.1.
DR   UCSC; uc011bld.2; human.
DR   CTD; 644974; -.
DR   GeneCards; ALG1L2; -.
DR   HGNC; HGNC:37258; ALG1L2.
DR   HPA; ENSG00000251287; Tissue enhanced (brain, retina).
DR   neXtProt; NX_C9J202; -.
DR   PharmGKB; PA165696819; -.
DR   VEuPathDB; HostDB:ENSG00000251287; -.
DR   eggNOG; KOG2941; Eukaryota.
DR   GeneTree; ENSGT00390000008647; -.
DR   HOGENOM; CLU_012079_2_1_1; -.
DR   InParanoid; C9J202; -.
DR   OMA; CIPWLEG; -.
DR   OrthoDB; 816895at2759; -.
DR   PhylomeDB; C9J202; -.
DR   BioGRID-ORCS; 644974; 4 hits in 117 CRISPR screens.
DR   GenomeRNAi; 644974; -.
DR   Pharos; C9J202; Tdark.
DR   PRO; PR:C9J202; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   RNAct; C9J202; protein.
DR   Bgee; ENSG00000251287; Expressed in calcaneal tendon and 95 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0000030; F:mannosyltransferase activity; IBA:GO_Central.
DR   GO; GO:0006486; P:protein glycosylation; IBA:GO_Central.
DR   InterPro; IPR026051; ALG1-like.
DR   PANTHER; PTHR13036; PTHR13036; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..215
FT                   /note="Putative glycosyltransferase ALG1L2"
FT                   /id="PRO_0000393966"
FT   REGION          40..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        42..58
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   215 AA;  24154 MW;  FE270225343D6A1C CRC64;
     MGATAGWAVT VYDKPASFFK EAPLDLQHRL FMKLGSTHSP FRARSEPEDP DTERSAFTER
     DSGSGLVTRL HERPALLVSS TSWTEFEQLT LDGQNLPSLV CVITGKGPLR EYYSRLIHQK
     HFQHIQVCIP WLEGRGLPPL LGSVDLDVCL DTSSSGLDLP MKVVDMFRCC LPACAVNFKC
     LHELVKHEEN RLVFEDSEEL AAQLQYFADA FLKLS