ID   AG1_XENLA               Reviewed;         183 AA.
AC   P55868; Q5D0A7;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Anterior gradient protein 1;
DE            Short=XAG-1;
DE   AltName: Full=XAG;
DE   Flags: Precursor;
GN   Name=ag1; Synonyms=ag;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Embryonic head;
RX   PubMed=2752418; DOI=10.1016/0092-8674(89)90413-3;
RA   Sive H.L., Hattori K., Weintraub H.;
RT   "Progressive determination during formation of the anteroposterior axis in
RT   Xenopus laevis.";
RL   Cell 58:171-180(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tail bud;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=1723941; DOI=10.1242/dev.110.2.325;
RA   Hemmati-Brivanlou A., Frank D., Bolce M.E., Brown B.D., Sive H.L.,
RA   Harland R.M.;
RT   "Localization of specific mRNAs in Xenopus embryos by whole-mount in situ
RT   hybridization.";
RL   Development 110:325-330(1990).
RN   [4]
RP   LACK OF FUNCTION IN CEMENT GLAND FORMATION.
RX   PubMed=9533957; DOI=10.1016/s0925-4773(98)00021-5;
RA   Aberger F., Weidinger G., Grunz H., Richter K.;
RT   "Anterior specification of embryonic ectoderm: the role of the Xenopus
RT   cement gland-specific gene XAG-2.";
RL   Mech. Dev. 72:115-130(1998).
CC   -!- FUNCTION: Does not appear to be required for cement gland formation.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: From stage 18 (neurula) onward, expressed in the
CC       cement gland until it degenerates. More weakly expressed in the
CC       adjacent hatching gland. {ECO:0000269|PubMed:1723941,
CC       ECO:0000269|PubMed:2752418}.
CC   -!- SIMILARITY: Belongs to the AGR family. {ECO:0000305}.
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DR   EMBL; U76752; AAB18819.1; -; mRNA.
DR   EMBL; BC046838; AAH46838.1; -; mRNA.
DR   RefSeq; NP_001079667.1; NM_001086198.1.
DR   AlphaFoldDB; P55868; -.
DR   SMR; P55868; -.
DR   DNASU; 379354; -.
DR   GeneID; 379354; -.
DR   KEGG; xla:379354; -.
DR   CTD; 379354; -.
DR   Xenbase; XB-GENE-5866216; ag1.L.
DR   OMA; SRGWADE; -.
DR   OrthoDB; 1382017at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 379354; Expressed in stomach and 9 other tissues.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..183
FT                   /note="Anterior gradient protein 1"
FT                   /id="PRO_0000001042"
SQ   SEQUENCE   183 AA;  20475 MW;  95E12B06FCB8DCE8 CRC64;
     MQAGLSLVCL VLLCSALGEA VLKKPKKQAG TTDTKTDQEP APIKTKGLKT LDRGWGESIE
     WVQTYEEGLA KARENNKPLM VIHHLEDCPY SIALKKAFVA DRMAQKLAQE DFIMLNLVHP
     VADENQSPDG HYVPRVIFID PSLTVRSDLK GRYGNKMYAY DADDIPELIT NMKKAKSFLK
     TEL