EIF3I_PICST
ID EIF3I_PICST Reviewed; 350 AA.
AC A3LX18;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit I {ECO:0000255|HAMAP-Rule:MF_03008};
DE Short=eIF3i {ECO:0000255|HAMAP-Rule:MF_03008};
DE AltName: Full=Eukaryotic translation initiation factor 3 39 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03008};
DE Short=eIF-3 39 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03008};
GN Name=TIF34 {ECO:0000255|HAMAP-Rule:MF_03008}; ORFNames=PICST_90188;
OS Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS Y-11545) (Yeast) (Pichia stipitis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX NCBI_TaxID=322104;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX PubMed=17334359; DOI=10.1038/nbt1290;
RA Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA Passoth V., Richardson P.M.;
RT "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT yeast Pichia stipitis.";
RL Nat. Biotechnol. 25:319-326(2007).
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03008}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03008}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03008}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit I family. {ECO:0000255|HAMAP-
CC Rule:MF_03008}.
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DR EMBL; CP000500; ABN67385.1; -; Genomic_DNA.
DR RefSeq; XP_001385414.1; XM_001385377.1.
DR AlphaFoldDB; A3LX18; -.
DR SMR; A3LX18; -.
DR STRING; 4924.XP_001385414.1; -.
DR EnsemblFungi; ABN67385; ABN67385; PICST_90188.
DR GeneID; 4840077; -.
DR KEGG; pic:PICST_90188; -.
DR eggNOG; KOG0643; Eukaryota.
DR HOGENOM; CLU_043845_0_1_1; -.
DR InParanoid; A3LX18; -.
DR OMA; VWFSHNG; -.
DR OrthoDB; 866359at2759; -.
DR Proteomes; UP000002258; Chromosome 6.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03008; eIF3i; 1.
DR InterPro; IPR027525; eIF3i.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW Repeat; WD repeat.
FT CHAIN 1..350
FT /note="Eukaryotic translation initiation factor 3 subunit
FT I"
FT /id="PRO_0000366902"
FT REPEAT 8..49
FT /note="WD 1"
FT REPEAT 51..89
FT /note="WD 2"
FT REPEAT 91..135
FT /note="WD 3"
FT REPEAT 149..188
FT /note="WD 4"
FT REPEAT 198..240
FT /note="WD 5"
FT REPEAT 296..335
FT /note="WD 6"
SQ SEQUENCE 350 AA; 38374 MW; 6CFB39553BB39176 CRC64;
MRPIKLMGHE RSLTQVKYNR EGDLLFSVAK DNAASIWYSS NGERLGTLEG HQGVIWSIDV
DPDTHLCATG GGDLAIKLWK VETGKCVFTW ESPSPVRRVA FSPDGSRLLA IADQVMGHIG
TIVVYEINHD DESLTNQSTE PSLVIETPQD GAKATVAGWS ANGEFIISGH DDGYIYKYDA
QTGEAVNSLE AHGIHTEEKN VTVTDIQFAA EDRSYFITSS KDKCSTLIDV DTFEILKVYK
ADAPMNTAAI TPLKDFVILG GGQEARNVTT TAESQGKFEA RFYHKVFEDE IGRVKGHFGP
LNTVAVHPDG TGYSSGGEDG FIRVHTFDKS YFDFYVDAAE KNTEKSAEKA
