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EIF3I_RAT
ID   EIF3I_RAT               Reviewed;         325 AA.
AC   B0BNA7;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit I {ECO:0000255|HAMAP-Rule:MF_03008};
DE            Short=eIF3i {ECO:0000255|HAMAP-Rule:MF_03008};
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit 2 {ECO:0000255|HAMAP-Rule:MF_03008};
DE   AltName: Full=eIF-3-beta {ECO:0000255|HAMAP-Rule:MF_03008};
DE   AltName: Full=eIF3 p36 {ECO:0000255|HAMAP-Rule:MF_03008};
GN   Name=Eif3i; Synonyms=Eif3s2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is required for several steps in the initiation
CC       of protein synthesis. The eIF-3 complex associates with the 40S
CC       ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-
CC       2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex
CC       (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC
CC       and scanning of the mRNA for AUG recognition. The eIF-3 complex is also
CC       required for disassembly and recycling of post-termination ribosomal
CC       complexes and subsequently prevents premature joining of the 40S and
CC       60S ribosomal subunits prior to initiation. The eIF-3 complex
CC       specifically targets and initiates translation of a subset of mRNAs
CC       involved in cell proliferation, including cell cycling, differentiation
CC       and apoptosis, and uses different modes of RNA stem-loop binding to
CC       exert either translational activation or repression.
CC       {ECO:0000255|HAMAP-Rule:MF_03008}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C,
CC       EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and
CC       EIF3M. The eIF-3 complex appears to include 3 stable modules: module A
CC       is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of
CC       EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D,
CC       EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and
CC       EIF3H of module B, thereby linking the three modules. EIF3J is a labile
CC       subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex
CC       interacts with RPS6KB1 under conditions of nutrient depletion.
CC       Mitogenic stimulation leads to binding and activation of a complex
CC       composed of MTOR and RPTOR, leading to phosphorylation and release of
CC       RPS6KB1 and binding of EIF4B to eIF-3. {ECO:0000255|HAMAP-
CC       Rule:MF_03008}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03008}.
CC   -!- PTM: Phosphorylated by TGF-beta type II receptor. {ECO:0000255|HAMAP-
CC       Rule:MF_03008}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit I family. {ECO:0000255|HAMAP-
CC       Rule:MF_03008}.
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DR   EMBL; BC158748; AAI58749.1; -; mRNA.
DR   EMBL; BC158821; AAI58822.1; -; mRNA.
DR   RefSeq; NP_001108507.1; NM_001115035.1.
DR   AlphaFoldDB; B0BNA7; -.
DR   SMR; B0BNA7; -.
DR   BioGRID; 597308; 1.
DR   IntAct; B0BNA7; 2.
DR   iPTMnet; B0BNA7; -.
DR   PhosphoSitePlus; B0BNA7; -.
DR   jPOST; B0BNA7; -.
DR   PeptideAtlas; B0BNA7; -.
DR   PRIDE; B0BNA7; -.
DR   GeneID; 682390; -.
DR   KEGG; rno:682390; -.
DR   CTD; 8668; -.
DR   RGD; 1584560; Eif3i.
DR   InParanoid; B0BNA7; -.
DR   OrthoDB; 866359at2759; -.
DR   PhylomeDB; B0BNA7; -.
DR   Reactome; R-RNO-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-RNO-72649; Translation initiation complex formation.
DR   Reactome; R-RNO-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-RNO-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR   Reactome; R-RNO-72702; Ribosomal scanning and start codon recognition.
DR   Reactome; R-RNO-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR   PRO; PR:B0BNA7; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:UniProtKB.
DR   GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; ISO:RGD.
DR   GO; GO:0019899; F:enzyme binding; IPI:RGD.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003743; F:translation initiation factor activity; ISS:UniProtKB.
DR   GO; GO:0002183; P:cytoplasmic translational initiation; IBA:GO_Central.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0006413; P:translational initiation; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03008; eIF3i; 1.
DR   InterPro; IPR027525; eIF3i.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 3.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Initiation factor; Isopeptide bond; Phosphoprotein;
KW   Protein biosynthesis; Reference proteome; Repeat; Ubl conjugation;
KW   WD repeat.
FT   CHAIN           1..325
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   I"
FT                   /id="PRO_0000329458"
FT   REPEAT          8..47
FT                   /note="WD 1"
FT   REPEAT          50..91
FT                   /note="WD 2"
FT   REPEAT          144..183
FT                   /note="WD 3"
FT   REPEAT          186..225
FT                   /note="WD 4"
FT   REPEAT          283..324
FT                   /note="WD 5"
FT   MOD_RES         264
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q13347"
FT   MOD_RES         308
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q13347"
FT   CROSSLNK        282
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in ubiquitin)"
FT                   /evidence="ECO:0000250|UniProtKB:Q13347"
SQ   SEQUENCE   325 AA;  36461 MW;  FCEF0FCFB7D20D16 CRC64;
     MKPILLQGHE RSITQIKYNR EGDLLFTVAK DPIVNVWYSV NGERLGTYMG HTGAVWCVDA
     DWDTKHVLTG SADNSCRLWD CETGKQLALL KTNSAVRTCG FDFGGNIIMF STDKQMGYQC
     FVSFFDLRDP SQIDSNEPYM KIPCNDSKIT SAVWGPLGEC IIAGHESGEL NQYSAKSGEV
     LVNVKEHSRQ INDIQLSRDM TMFVTASKDN TAKLFDSTSL EHQKTFRTER PVNSAALSPN
     YDHVVLGGGQ EAMDVTTTST RIGKFEARFF HLAFEEEFGR VKGHFGPINS VAFHPDGKSY
     SSGGEDGYVR IHYFDPQYFE FEFEA
 
 
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