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EIF3I_TAEGU
ID   EIF3I_TAEGU             Reviewed;         325 AA.
AC   B5FZ19; B5FZ20;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 2.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit I {ECO:0000255|HAMAP-Rule:MF_03008};
DE            Short=eIF3i {ECO:0000255|HAMAP-Rule:MF_03008};
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit 2 {ECO:0000255|HAMAP-Rule:MF_03008};
DE   AltName: Full=eIF-3-beta {ECO:0000255|HAMAP-Rule:MF_03008};
DE   AltName: Full=eIF3 p36 {ECO:0000255|HAMAP-Rule:MF_03008};
GN   Name=EIF3I {ECO:0000255|HAMAP-Rule:MF_03008};
GN   Synonyms=EIF3S2 {ECO:0000255|HAMAP-Rule:MF_03008};
OS   Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC   Estrildinae; Taeniopygia.
OX   NCBI_TaxID=59729;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=17018643; DOI=10.1073/pnas.0607098103;
RA   Wada K., Howard J.T., McConnell P., Whitney O., Lints T., Rivas M.V.,
RA   Horita H., Patterson M.A., White S.A., Scharff C., Haesler S., Zhao S.,
RA   Sakaguchi H., Hagiwara M., Shiraki T., Hirozane-Kishikawa T., Skene P.,
RA   Hayashizaki Y., Carninci P., Jarvis E.D.;
RT   "A molecular neuroethological approach for identifying and characterizing a
RT   cascade of behaviorally regulated genes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15212-15217(2006).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03008}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C,
CC       EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and
CC       EIF3M. {ECO:0000255|HAMAP-Rule:MF_03008}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03008}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit I family. {ECO:0000255|HAMAP-
CC       Rule:MF_03008}.
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DR   EMBL; DQ214273; ACH44280.1; -; mRNA.
DR   EMBL; DQ214274; ACH44281.1; -; mRNA.
DR   EMBL; DQ214277; ACH44283.1; -; mRNA.
DR   EMBL; DQ214278; ACH44284.1; -; mRNA.
DR   EMBL; DQ214279; ACH44285.1; -; mRNA.
DR   EMBL; DQ214280; ACH44286.1; -; mRNA.
DR   RefSeq; NP_001157823.1; NM_001164351.1.
DR   RefSeq; XP_012426053.1; XM_012570599.1.
DR   AlphaFoldDB; B5FZ19; -.
DR   SMR; B5FZ19; -.
DR   STRING; 59729.ENSTGUP00000001453; -.
DR   Ensembl; ENSTGUT00000001466; ENSTGUP00000001453; ENSTGUG00000001395.
DR   GeneID; 100190672; -.
DR   KEGG; tgu:100190672; -.
DR   CTD; 8668; -.
DR   GeneTree; ENSGT00940000161371; -.
DR   InParanoid; B5FZ19; -.
DR   OrthoDB; 866359at2759; -.
DR   Proteomes; UP000007754; Chromosome 23.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:UniProtKB.
DR   GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IEA:Ensembl.
DR   GO; GO:0003743; F:translation initiation factor activity; ISS:UniProtKB.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0006413; P:translational initiation; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03008; eIF3i; 1.
DR   InterPro; IPR027525; eIF3i.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 4.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 4.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW   Repeat; WD repeat.
FT   CHAIN           1..325
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   I"
FT                   /id="PRO_0000365331"
FT   REPEAT          8..47
FT                   /note="WD 1"
FT   REPEAT          50..89
FT                   /note="WD 2"
FT   REPEAT          144..183
FT                   /note="WD 3"
FT   REPEAT          186..225
FT                   /note="WD 4"
FT   REPEAT          283..324
FT                   /note="WD 5"
FT   CONFLICT        12
FT                   /note="S -> F (in Ref. 1; ACH44280)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        299..300
FT                   /note="SY -> KN (in Ref. 1; ACH44280)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   325 AA;  36502 MW;  94FAF99FF8A23F05 CRC64;
     MKPILLQGHE RSITQIKYNR EGDLLFTVAK DPIVNVWYSV NGERLGTYNG HTGAVWCVDA
     DWDTRHVLTG SADNSCRLWD CETGKQLALV KTSSAVRTCG FDFGGNIIMF STDKQMGYQC
     FVSFFDLRDP SQIENNEPYM KIPCSDSKIT SAVWGPLGEF IIAGHENGEL NQFSAKSGEQ
     LSNIKEHTKQ INDIQTSRDM TMFITASKDN TAKLFDCTSL KHLKTFRTER PVNSAALSPI
     FDHVVLGGGQ EAMDVTTTST RIGKFEARFF HLAFEEEFGR VKGHFGPINS VAFHPDGKSY
     SSGGEDGYVR IHYFDPQYFE FEFEA
 
 
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