ID   EIF3I_VANPO             Reviewed;         347 AA.
AC   A7TH19;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit I {ECO:0000255|HAMAP-Rule:MF_03008};
DE            Short=eIF3i {ECO:0000255|HAMAP-Rule:MF_03008};
DE   AltName: Full=Eukaryotic translation initiation factor 3 39 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03008};
DE            Short=eIF-3 39 kDa subunit homolog {ECO:0000255|HAMAP-Rule:MF_03008};
GN   Name=TIF34 {ECO:0000255|HAMAP-Rule:MF_03008}; ORFNames=Kpol_1032p65;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03008}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex. {ECO:0000255|HAMAP-Rule:MF_03008}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03008}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit I family. {ECO:0000255|HAMAP-
CC       Rule:MF_03008}.
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DR   EMBL; DS480389; EDO18471.1; -; Genomic_DNA.
DR   RefSeq; XP_001646329.1; XM_001646279.1.
DR   AlphaFoldDB; A7TH19; -.
DR   SMR; A7TH19; -.
DR   STRING; 436907.A7TH19; -.
DR   EnsemblFungi; EDO18471; EDO18471; Kpol_1032p65.
DR   GeneID; 5546758; -.
DR   KEGG; vpo:Kpol_1032p65; -.
DR   eggNOG; KOG0643; Eukaryota.
DR   HOGENOM; CLU_043845_0_1_1; -.
DR   InParanoid; A7TH19; -.
DR   OMA; VWFSHNG; -.
DR   OrthoDB; 866359at2759; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03008; eIF3i; 1.
DR   InterPro; IPR024977; Apc4_WD40_dom.
DR   InterPro; IPR027525; eIF3i.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF12894; ANAPC4_WD40; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW   Repeat; WD repeat.
FT   CHAIN           1..347
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   I"
FT                   /id="PRO_0000365374"
FT   REPEAT          8..47
FT                   /note="WD 1"
FT   REPEAT          50..89
FT                   /note="WD 2"
FT   REPEAT          91..135
FT                   /note="WD 3"
FT   REPEAT          151..190
FT                   /note="WD 4"
FT   REPEAT          193..232
FT                   /note="WD 5"
FT   REPEAT          290..329
FT                   /note="WD 6"
SQ   SEQUENCE   347 AA;  38749 MW;  C6007656EF7A0ADF CRC64;
     MRPIMLVGHE RPLTQVKYNK EGDLVFSCSK DSVASVWYSI NGERLGTLEG HTGTIWSIDV
     DPFTESCVTG SADYSIKVWK VQTGTVIHTW TAPVPIKRVE FSPCGDYILA VLDDVMRYPG
     SINVYKVSRD PVTKEIKEFV EEPILVINTQ ENHKGVTVAG WSAEGKYIIA CHKDGKVSKY
     NAKTGEFITS IELHTQTIGD IQFSPDRTYF ITSSRDSMAY ILDVESMEQL KSYEADCPLN
     SACITPLKEF VILGGGQAAR DVTTTSAREG KFEARFYHKI FEDEIGRVKG HFGPLNYVAV
     NPQGTSYTSG GEDGFARIHH FEKSYFDFKY DVEKAAEAKE HMQTASA