ID   AG1_XENTR               Reviewed;         187 AA.
AC   Q6NVS9;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Anterior gradient protein 1;
DE   Flags: Precursor;
GN   Name=ag1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:AAH67924.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula {ECO:0000312|EMBL:AAH67924.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probably involved in cement gland formation.
CC       {ECO:0000250|UniProtKB:P55869}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000255, ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the AGR family. {ECO:0000255}.
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DR   EMBL; BC067924; AAH67924.1; -; mRNA.
DR   RefSeq; NP_998864.1; NM_213699.1.
DR   AlphaFoldDB; Q6NVS9; -.
DR   SMR; Q6NVS9; -.
DR   STRING; 8364.ENSXETP00000062478; -.
DR   DNASU; 407906; -.
DR   Ensembl; ENSXETT00000010586; ENSXETP00000010586; ENSXETG00000004878.
DR   GeneID; 407906; -.
DR   KEGG; xtr:407906; -.
DR   CTD; 407906; -.
DR   Xenbase; XB-GENE-5866013; ag1.
DR   eggNOG; ENOG502R72A; Eukaryota.
DR   InParanoid; Q6NVS9; -.
DR   OrthoDB; 1382017at2759; -.
DR   Proteomes; UP000008143; Chromosome 9.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000004878; Expressed in neurula embryo and 13 other tissues.
DR   ExpressionAtlas; Q6NVS9; baseline.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR   GO; GO:0060548; P:negative regulation of cell death; IBA:GO_Central.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..187
FT                   /note="Anterior gradient protein 1"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000392576"
SQ   SEQUENCE   187 AA;  20885 MW;  87EF96D86FD5E857 CRC64;
     MQTGLSLVCL VLLCSALGEA ALRKTKKQAV VTDTGNSAKS DPEPVPIKTK GLKTLDRGWG
     EEIEWVQTYE EGLAKARENN KPLMVIHHLE DCPYSIALKK AFVADRLAQK LAREDFIMLN
     LVHPVADENQ APDGHYVPRV IFVDPSLTVR SDLKGRYGNK MYAYDADDIP ELVTNMKKAK
     SYLKTEL