ID   EIF3I_XENLA             Reviewed;         325 AA.
AC   Q66J51;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Eukaryotic translation initiation factor 3 subunit I {ECO:0000255|HAMAP-Rule:MF_03008};
DE            Short=eIF3i {ECO:0000255|HAMAP-Rule:MF_03008};
DE   AltName: Full=Eukaryotic translation initiation factor 3 subunit 2 {ECO:0000255|HAMAP-Rule:MF_03008};
DE   AltName: Full=eIF-3-beta {ECO:0000255|HAMAP-Rule:MF_03008};
DE   AltName: Full=eIF3 p36 {ECO:0000255|HAMAP-Rule:MF_03008};
GN   Name=eif3i; Synonyms=eif3s2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is involved in protein synthesis of a
CC       specialized repertoire of mRNAs and, together with other initiation
CC       factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC       ribosome. The eIF-3 complex specifically targets and initiates
CC       translation of a subset of mRNAs involved in cell proliferation.
CC       {ECO:0000255|HAMAP-Rule:MF_03008}.
CC   -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC       (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c,
CC       eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and
CC       eif3m. {ECO:0000255|HAMAP-Rule:MF_03008}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03008}.
CC   -!- SIMILARITY: Belongs to the eIF-3 subunit I family. {ECO:0000255|HAMAP-
CC       Rule:MF_03008}.
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DR   EMBL; BC081058; AAH81058.1; -; mRNA.
DR   RefSeq; NP_001087664.1; NM_001094195.1.
DR   AlphaFoldDB; Q66J51; -.
DR   SMR; Q66J51; -.
DR   BioGRID; 104348; 2.
DR   IntAct; Q66J51; 1.
DR   DNASU; 447488; -.
DR   GeneID; 447488; -.
DR   KEGG; xla:447488; -.
DR   CTD; 447488; -.
DR   Xenbase; XB-GENE-974385; eif3i.L.
DR   OMA; VWFSHNG; -.
DR   OrthoDB; 866359at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 447488; Expressed in spleen and 19 other tissues.
DR   GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:UniProtKB.
DR   GO; GO:0003743; F:translation initiation factor activity; ISS:UniProtKB.
DR   GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0006413; P:translational initiation; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   HAMAP; MF_03008; eIF3i; 1.
DR   InterPro; IPR024977; Apc4_WD40_dom.
DR   InterPro; IPR027525; eIF3i.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF12894; ANAPC4_WD40; 1.
DR   Pfam; PF00400; WD40; 3.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome;
KW   Repeat; WD repeat.
FT   CHAIN           1..325
FT                   /note="Eukaryotic translation initiation factor 3 subunit
FT                   I"
FT                   /id="PRO_0000365333"
FT   REPEAT          8..47
FT                   /note="WD 1"
FT   REPEAT          50..91
FT                   /note="WD 2"
FT   REPEAT          144..183
FT                   /note="WD 3"
FT   REPEAT          186..225
FT                   /note="WD 4"
FT   REPEAT          283..324
FT                   /note="WD 5"
SQ   SEQUENCE   325 AA;  36496 MW;  FE117441A632BEF3 CRC64;
     MRPILLQGHE RSITQIKYNR DGDLLFTVAK DPVVNVWYSV NGERLGTYNG HTGAVWCVDV
     DWETRHVLSG SADNSCRLWD CETGKQLALL QTNSAVRTCG FDFGGNIIMF STDKQMGYQC
     FVSFIDLRDP SQIEDNEPYM KIPCSESKIT SAVWGPLGEN IIAGHENGEL NHYSAKSGEI
     VNSIKEHSKQ INDIQTSRDM TMFVTASKDC TSKLFDSTSL EHQKTFRTER PVNSAAVSPI
     YDHVVLGGGQ EAMDVTTTST RIGKFEARFF HVAFEEEFGR VKGHFGPINS LAFHPDGKSY
     SSGGEDGYVR IHYFDPQYFD FEFES