EIF3I_XENTR
ID EIF3I_XENTR Reviewed; 325 AA.
AC Q5EBE8; A1L0Z7;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit I {ECO:0000255|HAMAP-Rule:MF_03008};
DE Short=eIF3i {ECO:0000255|HAMAP-Rule:MF_03008};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 2 {ECO:0000255|HAMAP-Rule:MF_03008};
DE AltName: Full=eIF-3-beta {ECO:0000255|HAMAP-Rule:MF_03008};
DE AltName: Full=eIF3 p36 {ECO:0000255|HAMAP-Rule:MF_03008};
GN Name=eif3i; Synonyms=eif3s2; ORFNames=TGas097i03.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Gastrula;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Fat body, and Thymus;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03008}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is composed of 13 subunits: eif3a, eif3b, eif3c,
CC eif3d, eif3e, eif3f, eif3g, eif3h, eif3i, eif3j, eif3k, eif3l and
CC eif3m. {ECO:0000255|HAMAP-Rule:MF_03008}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03008}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5EBE8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5EBE8-2; Sequence=VSP_036501;
CC -!- SIMILARITY: Belongs to the eIF-3 subunit I family. {ECO:0000255|HAMAP-
CC Rule:MF_03008}.
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DR EMBL; CR855704; CAL49363.1; -; mRNA.
DR EMBL; BC089722; AAH89722.1; -; mRNA.
DR EMBL; BC127352; AAI27353.1; -; mRNA.
DR EMBL; BC157539; AAI57540.1; -; mRNA.
DR RefSeq; NP_001015781.1; NM_001015781.1. [Q5EBE8-1]
DR AlphaFoldDB; Q5EBE8; -.
DR SMR; Q5EBE8; -.
DR PaxDb; Q5EBE8; -.
DR DNASU; 548498; -.
DR GeneID; 548498; -.
DR KEGG; xtr:548498; -.
DR CTD; 8668; -.
DR Xenbase; XB-GENE-974377; eif3i.
DR eggNOG; KOG0643; Eukaryota.
DR HOGENOM; CLU_043845_0_0_1; -.
DR InParanoid; Q5EBE8; -.
DR OMA; VWFSHNG; -.
DR OrthoDB; 866359at2759; -.
DR PhylomeDB; Q5EBE8; -.
DR TreeFam; TF101515; -.
DR Reactome; R-XTR-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-XTR-72649; Translation initiation complex formation.
DR Reactome; R-XTR-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-XTR-72702; Ribosomal scanning and start codon recognition.
DR Proteomes; UP000008143; Chromosome 2.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000005247; Expressed in heart and 12 other tissues.
DR ExpressionAtlas; Q5EBE8; differential.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:UniProtKB.
DR GO; GO:0071541; C:eukaryotic translation initiation factor 3 complex, eIF3m; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003743; F:translation initiation factor activity; ISS:UniProtKB.
DR GO; GO:0002183; P:cytoplasmic translational initiation; IBA:GO_Central.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006413; P:translational initiation; ISS:UniProtKB.
DR Gene3D; 2.130.10.10; -; 1.
DR HAMAP; MF_03008; eIF3i; 1.
DR InterPro; IPR027525; eIF3i.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 4.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cytoplasm; Initiation factor; Protein biosynthesis;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..325
FT /note="Eukaryotic translation initiation factor 3 subunit
FT I"
FT /id="PRO_0000365334"
FT REPEAT 8..47
FT /note="WD 1"
FT REPEAT 50..89
FT /note="WD 2"
FT REPEAT 144..183
FT /note="WD 3"
FT REPEAT 186..225
FT /note="WD 4"
FT REPEAT 283..324
FT /note="WD 5"
FT VAR_SEQ 316..325
FT /note="PQYFDFEFES -> THTHNCIDCSMISLQ (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_036501"
SQ SEQUENCE 325 AA; 36475 MW; 391B4CC83D979121 CRC64;
MRPILLQGHE RSITQIKYNR DGDLLFTVAK DPVVNVWYSV NGERLGTYSG HTGAVWCVDV
DWDTRHVLSG SADNSCRLWD CETGKQLALL ETNSAVRTCG FDFGGNIIMF STDKQMGYQC
FVSFIDLRDP TQIEDNEPYM KIPCSESKIT SAVWGPLGEN IIAGHENGEL NQYSAKSGEI
VNSIKEHSKQ INDIQTSRDM TMFVTASKDC TSKLFDSTSL EHQKTFRTER PVNSAAISPI
YDHVVLGGGQ EAMDVTTTST RIGKFEARFF HVAFEEEFGR VKGHFGPINS LAFHPDGKSY
SSGGEDGYVR IHYFDPQYFD FEFES
