EIF3J_CHICK
ID EIF3J_CHICK Reviewed; 252 AA.
AC Q5ZKA4;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit J {ECO:0000255|HAMAP-Rule:MF_03009};
DE Short=eIF3j {ECO:0000255|HAMAP-Rule:MF_03009};
DE AltName: Full=Eukaryotic translation initiation factor 3 subunit 1 {ECO:0000255|HAMAP-Rule:MF_03009};
DE AltName: Full=eIF-3-alpha {ECO:0000255|HAMAP-Rule:MF_03009};
DE AltName: Full=eIF3 p35 {ECO:0000255|HAMAP-Rule:MF_03009};
GN Name=EIF3J {ECO:0000255|HAMAP-Rule:MF_03009};
GN Synonyms=EIF3S1 {ECO:0000255|HAMAP-Rule:MF_03009}; ORFNames=RCJMB04_12b11;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03009}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C,
CC EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and
CC EIF3M. {ECO:0000255|HAMAP-Rule:MF_03009}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03009}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit J family. {ECO:0000255|HAMAP-
CC Rule:MF_03009}.
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DR EMBL; AJ720180; CAG31839.1; -; mRNA.
DR RefSeq; NP_001012789.1; NM_001012771.2.
DR AlphaFoldDB; Q5ZKA4; -.
DR SMR; Q5ZKA4; -.
DR STRING; 9031.ENSGALP00000013321; -.
DR PaxDb; Q5ZKA4; -.
DR Ensembl; ENSGALT00000013336; ENSGALP00000013321; ENSGALG00000008187.
DR GeneID; 415573; -.
DR KEGG; gga:415573; -.
DR CTD; 8669; -.
DR VEuPathDB; HostDB:geneid_415573; -.
DR eggNOG; KOG4813; Eukaryota.
DR GeneTree; ENSGT00390000018400; -.
DR HOGENOM; CLU_085806_2_1_1; -.
DR InParanoid; Q5ZKA4; -.
DR OMA; HYGLFLE; -.
DR OrthoDB; 1565510at2759; -.
DR PhylomeDB; Q5ZKA4; -.
DR Reactome; R-GGA-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-GGA-72702; Ribosomal scanning and start codon recognition.
DR PRO; PR:Q5ZKA4; -.
DR Proteomes; UP000000539; Chromosome 10.
DR Bgee; ENSGALG00000008187; Expressed in muscle tissue and 13 other tissues.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; ISS:UniProtKB.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.246.60; -; 1.
DR HAMAP; MF_03009; eIF3j; 1.
DR InterPro; IPR023194; eIF3-like_dom_sf.
DR InterPro; IPR013906; eIF3j.
DR PANTHER; PTHR21681; PTHR21681; 1.
DR Pfam; PF08597; eIF3_subunit; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; Initiation factor; Protein biosynthesis;
KW Reference proteome.
FT CHAIN 1..252
FT /note="Eukaryotic translation initiation factor 3 subunit
FT J"
FT /id="PRO_0000365123"
FT REGION 24..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 209..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 65..130
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03009"
FT COMPBIAS 34..57
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..107
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 252 AA; 28724 MW; D3614FD629E137DA CRC64;
MAAEADSWDA DTFEVVEPVA KRLVPAGVAG DRWAGEDEED DVKDNWDDEE EEEEVKEAEV
KQEPKVSEKK KIAEKIKEKE KQQKKKQEEL KKRLEAPEEH KELTPEEQLA DKLRLKKLQE
ESDLELAKET FGVNNACGID AMNPSSKDDF TEFGKLLKEK ITQYEKSLHY ASFLEALVRD
VCISLEIDDL KKITNSLTVL CSEKQKQEKQ SKAKKKKKGV VPGGGLKATM KDDLADYGGY
DGEYVQEFED FM
