ID   AG45_MYCLE              Reviewed;         429 AA.
AC   P46838;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   27-APR-2001, sequence version 2.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=46 kDa membrane protein;
GN   Name=ag45; OrderedLocusNames=ML1036;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7551058; DOI=10.1099/13500872-141-8-1963;
RA   Oskam L., Hartskeerl R.A., Hermans C.J., de Wit M.Y., Jarings G.H.,
RA   Nicholls R.D., Klatser P.R.;
RT   "A 46 kDa integral membrane protein from Mycobacterium leprae resembles a
RT   number of bacterial and mammalian membrane transport proteins.";
RL   Microbiology 141:1963-1968(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Smith D.R., Robison K.;
RL   Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CitM (TC 2.A.11) transporter family.
CC       {ECO:0000305}.
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DR   EMBL; L10660; AAA99493.1; -; Unassigned_DNA.
DR   EMBL; U15181; AAA62957.1; -; Genomic_DNA.
DR   EMBL; AL583920; CAC31417.1; -; Genomic_DNA.
DR   PIR; F87038; F87038.
DR   RefSeq; NP_301764.1; NC_002677.1.
DR   RefSeq; WP_010908088.1; NC_002677.1.
DR   AlphaFoldDB; P46838; -.
DR   SMR; P46838; -.
DR   STRING; 272631.ML1036; -.
DR   EnsemblBacteria; CAC31417; CAC31417; CAC31417.
DR   KEGG; mle:ML1036; -.
DR   PATRIC; fig|272631.5.peg.1867; -.
DR   Leproma; ML1036; -.
DR   eggNOG; COG1055; Bacteria.
DR   HOGENOM; CLU_011920_4_0_11; -.
DR   OMA; IAMFIDV; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015105; F:arsenite transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR000802; Arsenical_pump_ArsB.
DR   InterPro; IPR004680; Cit_transptr-like_dom.
DR   Pfam; PF03600; CitMHS; 1.
DR   PRINTS; PR00758; ARSENICPUMP.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..429
FT                   /note="46 kDa membrane protein"
FT                   /id="PRO_0000172512"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        224..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        279..299
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        315..335
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        360..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        407..427
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        151
FT                   /note="A -> R (in Ref. 1; AAA99493)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   429 AA;  46109 MW;  F8972B71604FD0AC CRC64;
     MSVIAITVFI VTYALIASDR VNKTLAALTG AAIVVTLPII NSEDVFYSHE TGIDWEVIFL
     LLSMMIIVSV LRQTGVFEYV AIWTAKRSHG SPLRILLLLV LVMALGSALL DNVTTVLLIA
     PVTLLVCERL TINAAPFLMA EVFASNIGGA ATLVGDPPNI IIASRAGFSF NDFLIHLTPI
     VIIVTVVLSA LLPRLFRGAF AVDPERVADI MSLNEREAIR DRWLLIKCGV VLLLVFVAFI
     AHPVLHTGPS LVGMLGAGIL IVISKLERSD YLSSVKWETL LFFAGLFIMV GALVKTDVVN
     QLARATTTLT GGHELLTVVL TLGVSTLVSS IIDNIPYVAT MTPIVSELVA SMPDQSHTDI
     LWWALALGAD FGGNLTAVGA SANVVMLEIA KSAGTPISFW EFTRKGIAVT VISIALAGIY
     LWLRYLVMS