EIF3J_DROWI
ID EIF3J_DROWI Reviewed; 236 AA.
AC B4MP81; Q8I166;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit J {ECO:0000255|HAMAP-Rule:MF_03009};
DE Short=eIF3j {ECO:0000255|HAMAP-Rule:MF_03009};
GN Name=eIF3j {ECO:0000255|HAMAP-Rule:MF_03009};
GN Synonyms=Adam {ECO:0000255|HAMAP-Rule:MF_03009}; ORFNames=GK21662;
OS Drosophila willistoni (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7260;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12537575; DOI=10.1186/gb-2002-3-12-research0086;
RA Bergman C.M., Pfeiffer B.D., Rincon-Limas D.E., Hoskins R.A., Gnirke A.,
RA Mungall C.J., Wang A.M., Kronmiller B., Pacleb J.M., Park S., Stapleton M.,
RA Wan K.H., George R.A., de Jong P.J., Botas J., Rubin G.M., Celniker S.E.;
RT "Assessing the impact of comparative genomic sequence data on the
RT functional annotation of the Drosophila genome.";
RL Genome Biol. 3:RESEARCH0086.1-RESEARCH0086.20(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14030-0811.24;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03009}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. The eIF-3 complex interacts with pix.
CC {ECO:0000255|HAMAP-Rule:MF_03009}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03009}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit J family. {ECO:0000255|HAMAP-
CC Rule:MF_03009}.
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DR EMBL; AY190959; AAO01104.1; -; Genomic_DNA.
DR EMBL; CH963849; EDW73920.1; -; Genomic_DNA.
DR RefSeq; XP_002062934.1; XM_002062898.2.
DR AlphaFoldDB; B4MP81; -.
DR SMR; B4MP81; -.
DR STRING; 7260.FBpp0250805; -.
DR EnsemblMetazoa; FBtr0252313; FBpp0250805; FBgn0064303.
DR GeneID; 6640598; -.
DR KEGG; dwi:6640598; -.
DR eggNOG; KOG4813; Eukaryota.
DR HOGENOM; CLU_085806_2_1_1; -.
DR InParanoid; B4MP81; -.
DR OMA; HYGLFLE; -.
DR OrthoDB; 1565510at2759; -.
DR PhylomeDB; B4MP81; -.
DR ChiTaRS; Adam; fly.
DR Proteomes; UP000007798; Unassembled WGS sequence.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006446; P:regulation of translational initiation; IEA:EnsemblMetazoa.
DR Gene3D; 1.10.246.60; -; 1.
DR HAMAP; MF_03009; eIF3j; 1.
DR InterPro; IPR023194; eIF3-like_dom_sf.
DR InterPro; IPR013906; eIF3j.
DR PANTHER; PTHR21681; PTHR21681; 1.
DR Pfam; PF08597; eIF3_subunit; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis; Reference proteome.
FT CHAIN 1..236
FT /note="Eukaryotic translation initiation factor 3 subunit
FT J"
FT /id="PRO_0000365142"
FT REGION 20..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..42
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..88
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 119
FT /note="T -> A (in Ref. 1; AAO01104)"
FT /evidence="ECO:0000305"
FT CONFLICT 171
FT /note="L -> V (in Ref. 1; AAO01104)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 236 AA; 27120 MW; 3E6D83D75B1FACF6 CRC64;
MADDWESAAD SEVVILPNAA NNINKWEGED DDEDVKESWE DEEEKKDEEK PTKTEVPVKP
KPTRALKAKL EEEERLREAE EEKRLANLTP EEKFAEKLRV KKMQEESDMK HTLDTFGVTS
ISGGLESFNP ESKEEFKEFG DTLSWKVAQF KESPHFPQFV EDLVRSICVN LSAADIKKVK
INVELLHSEK LKLEKANTKK PIGKGKGKVS LRTENDDIDG YQKYGNDFTD DYDDFM
