EIF3J_DROYA
ID EIF3J_DROYA Reviewed; 236 AA.
AC B4NX24;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 67.
DE RecName: Full=Eukaryotic translation initiation factor 3 subunit J {ECO:0000255|HAMAP-Rule:MF_03009};
DE Short=eIF3j {ECO:0000255|HAMAP-Rule:MF_03009};
GN Name=eIF3j {ECO:0000255|HAMAP-Rule:MF_03009};
GN Synonyms=Adam {ECO:0000255|HAMAP-Rule:MF_03009}; ORFNames=GE19320;
OS Drosophila yakuba (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tai18E2 / Tucson 14021-0261.01;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex, which is involved in protein synthesis of a
CC specialized repertoire of mRNAs and, together with other initiation
CC factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S
CC ribosome. The eIF-3 complex specifically targets and initiates
CC translation of a subset of mRNAs involved in cell proliferation.
CC {ECO:0000255|HAMAP-Rule:MF_03009}.
CC -!- SUBUNIT: Component of the eukaryotic translation initiation factor 3
CC (eIF-3) complex. The eIF-3 complex interacts with pix.
CC {ECO:0000255|HAMAP-Rule:MF_03009}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03009}.
CC -!- SIMILARITY: Belongs to the eIF-3 subunit J family. {ECO:0000255|HAMAP-
CC Rule:MF_03009}.
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DR EMBL; CM000157; EDW89585.1; -; Genomic_DNA.
DR RefSeq; XP_002089873.1; XM_002089837.2.
DR AlphaFoldDB; B4NX24; -.
DR SMR; B4NX24; -.
DR STRING; 7245.FBpp0264330; -.
DR EnsemblMetazoa; FBtr0265838; FBpp0264330; FBgn0236670.
DR GeneID; 6528841; -.
DR KEGG; dya:Dyak_GE19320; -.
DR eggNOG; KOG4813; Eukaryota.
DR HOGENOM; CLU_085806_2_0_1; -.
DR OMA; HYGLFLE; -.
DR OrthoDB; 1565510at2759; -.
DR PhylomeDB; B4NX24; -.
DR ChiTaRS; Adam; fly.
DR Proteomes; UP000002282; Chromosome 2L.
DR GO; GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0001732; P:formation of cytoplasmic translation initiation complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006446; P:regulation of translational initiation; IEA:EnsemblMetazoa.
DR Gene3D; 1.10.246.60; -; 1.
DR HAMAP; MF_03009; eIF3j; 1.
DR InterPro; IPR023194; eIF3-like_dom_sf.
DR InterPro; IPR013906; eIF3j.
DR PANTHER; PTHR21681; PTHR21681; 1.
DR Pfam; PF08597; eIF3_subunit; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Initiation factor; Protein biosynthesis.
FT CHAIN 1..236
FT /note="Eukaryotic translation initiation factor 3 subunit
FT J"
FT /id="PRO_0000365143"
FT REGION 1..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..42
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..82
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 236 AA; 26598 MW; 27215C27DCBF5A34 CRC64;
MADDWESAAD SEVVIRPTGA ASVNKWEGED EDEDIKDSWE DEEEKKDEEK PTKTEAPAKP
KPNKALKAKL EQQARLEEEA EAQRVANLSP AEKLAEKLRL QKIQEASDLK HAQEAFGVTS
TCGGLDAFNP ESKEEFKEFG ATLSWKVSQF RESEHFPQFV EDLVRSLCVN LSAADIKKVK
MNVEILHSEK LKLEKANAKK PAGKGKGKVT LRTENDDIDG YQKYGNDFTE DYDDFM
