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AGA11_HUMAN
ID   AGA11_HUMAN             Reviewed;         550 AA.
AC   Q8TF27; B9EIP7; D3DWE4;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 2.
DT   03-AUG-2022, entry version 143.
DE   RecName: Full=Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 11;
DE            Short=AGAP-11;
DE   AltName: Full=Centaurin-gamma-like protein KIAA1975;
GN   Name=AGAP11; Synonyms=KIAA1975;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=11853319; DOI=10.1093/dnares/8.6.319;
RA   Nagase T., Kikuno R., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XXII. The
RT   complete sequences of 50 new cDNA clones which code for large proteins.";
RL   DNA Res. 8:319-327(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT VAL-82.
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-82.
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Putative GTPase-activating protein. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the centaurin gamma-like family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB85561.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AL136982; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AB075855; BAB85561.1; ALT_INIT; mRNA.
DR   EMBL; CH471142; EAW80308.1; -; Genomic_DNA.
DR   EMBL; CH471142; EAW80307.1; -; Genomic_DNA.
DR   EMBL; CH471142; EAW80310.1; -; Genomic_DNA.
DR   EMBL; CH471142; EAW80311.1; -; Genomic_DNA.
DR   EMBL; BC140762; AAI40763.1; -; mRNA.
DR   RefSeq; NP_597704.1; NM_133447.1.
DR   AlphaFoldDB; Q8TF27; -.
DR   SMR; Q8TF27; -.
DR   BioGRID; 125637; 3.
DR   IntAct; Q8TF27; 2.
DR   MINT; Q8TF27; -.
DR   iPTMnet; Q8TF27; -.
DR   PhosphoSitePlus; Q8TF27; -.
DR   BioMuta; HGNC:29421; -.
DR   DMDM; 182641995; -.
DR   jPOST; Q8TF27; -.
DR   MassIVE; Q8TF27; -.
DR   MaxQB; Q8TF27; -.
DR   PeptideAtlas; Q8TF27; -.
DR   PRIDE; Q8TF27; -.
DR   ProteomicsDB; 74544; -.
DR   DNASU; 119385; -.
DR   GeneID; 119385; -.
DR   CTD; 119385; -.
DR   GeneCards; AGAP11; -.
DR   HGNC; HGNC:29421; AGAP11.
DR   neXtProt; NX_Q8TF27; -.
DR   PharmGKB; PA164715011; -.
DR   InParanoid; Q8TF27; -.
DR   OrthoDB; 751525at2759; -.
DR   PhylomeDB; Q8TF27; -.
DR   PathwayCommons; Q8TF27; -.
DR   SignaLink; Q8TF27; -.
DR   BioGRID-ORCS; 119385; 10 hits in 189 CRISPR screens.
DR   ChiTaRS; AGAP11; human.
DR   GenomeRNAi; 119385; -.
DR   Pharos; Q8TF27; Tdark.
DR   PRO; PR:Q8TF27; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q8TF27; protein.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR   Gene3D; 1.10.220.150; -; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   Gene3D; 2.30.29.30; -; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR037278; ARFGAP/RecO.
DR   InterPro; IPR001164; ArfGAP_dom.
DR   InterPro; IPR038508; ArfGAP_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF01412; ArfGap; 1.
DR   PRINTS; PR00405; REVINTRACTNG.
DR   SMART; SM00248; ANK; 2.
DR   SMART; SM00105; ArfGap; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   SUPFAM; SSF57863; SSF57863; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
DR   PROSITE; PS50115; ARFGAP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   ANK repeat; GTPase activation; Metal-binding; Reference proteome; Repeat;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..550
FT                   /note="Arf-GAP with GTPase, ANK repeat and PH domain-
FT                   containing protein 11"
FT                   /id="PRO_0000328758"
FT   DOMAIN          121..307
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   DOMAIN          328..448
FT                   /note="Arf-GAP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00288"
FT   REPEAT          487..516
FT                   /note="ANK 1"
FT   REPEAT          520..549
FT                   /note="ANK 2"
FT   ZN_FING         343..366
FT                   /note="C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00288"
FT   REGION          232..270
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        255..270
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         82
FT                   /note="I -> V (in dbSNP:rs2641563)"
FT                   /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.2"
FT                   /id="VAR_042518"
SQ   SEQUENCE   550 AA;  60549 MW;  A3A6A204B3ACC967 CRC64;
     MTIISVTLEI HHHITERDAD RSLTILDEQL YSFAFSTVHI TKKRNGGGSL NNYSSSIPLT
     PSTSQEDLYF SVPPTANTPT PICKQSMGWS NLFTSEKGSD PDKGRKALES HADTIGSGRA
     IPIKQGMLLK RSGKWLKTWK KKYVTLCSNG VLTYYSSLGD YMKNIHKKEI DLRTSTIKVP
     GKWPSLATSA CAPISSSKSN GLSKDMEALH MSANSDIGLG DSICFSPSIS STTSPKLNLP
     PSPHANKKKH LKKKSTNNLK DDGLSSTAEE EEEKFMIVSV TGQTCHFKAT TYEERDAWVQ
     AIQSQILASL QSCESSKSKS QLTSQSEAMA LQSIQNMRGN SHCVDCETQN PKWASLNLGV
     LMCIECSGIH RSLGTRLSRV RSLELDDWPV ELRKVMSSIG NDLANSIWEG SSQGQTKPSI
     ESTREEKERW IRSKYEHKLF LAPLPCTELS LGQHLLRATA DEDLRTAILL LAHGSREEVN
     ETCGEGDGCT ALHLACRKGN VVLAQLLIWY GVDVMARDAH GNTALTYARQ ASSQECINVL
     LQYGCPDECV
 
 
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