AGA11_HUMAN
ID AGA11_HUMAN Reviewed; 550 AA.
AC Q8TF27; B9EIP7; D3DWE4;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 2.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 11;
DE Short=AGAP-11;
DE AltName: Full=Centaurin-gamma-like protein KIAA1975;
GN Name=AGAP11; Synonyms=KIAA1975;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=11853319; DOI=10.1093/dnares/8.6.319;
RA Nagase T., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XXII. The
RT complete sequences of 50 new cDNA clones which code for large proteins.";
RL DNA Res. 8:319-327(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT VAL-82.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-82.
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Putative GTPase-activating protein. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the centaurin gamma-like family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB85561.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL136982; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AB075855; BAB85561.1; ALT_INIT; mRNA.
DR EMBL; CH471142; EAW80308.1; -; Genomic_DNA.
DR EMBL; CH471142; EAW80307.1; -; Genomic_DNA.
DR EMBL; CH471142; EAW80310.1; -; Genomic_DNA.
DR EMBL; CH471142; EAW80311.1; -; Genomic_DNA.
DR EMBL; BC140762; AAI40763.1; -; mRNA.
DR RefSeq; NP_597704.1; NM_133447.1.
DR AlphaFoldDB; Q8TF27; -.
DR SMR; Q8TF27; -.
DR BioGRID; 125637; 3.
DR IntAct; Q8TF27; 2.
DR MINT; Q8TF27; -.
DR iPTMnet; Q8TF27; -.
DR PhosphoSitePlus; Q8TF27; -.
DR BioMuta; HGNC:29421; -.
DR DMDM; 182641995; -.
DR jPOST; Q8TF27; -.
DR MassIVE; Q8TF27; -.
DR MaxQB; Q8TF27; -.
DR PeptideAtlas; Q8TF27; -.
DR PRIDE; Q8TF27; -.
DR ProteomicsDB; 74544; -.
DR DNASU; 119385; -.
DR GeneID; 119385; -.
DR CTD; 119385; -.
DR GeneCards; AGAP11; -.
DR HGNC; HGNC:29421; AGAP11.
DR neXtProt; NX_Q8TF27; -.
DR PharmGKB; PA164715011; -.
DR InParanoid; Q8TF27; -.
DR OrthoDB; 751525at2759; -.
DR PhylomeDB; Q8TF27; -.
DR PathwayCommons; Q8TF27; -.
DR SignaLink; Q8TF27; -.
DR BioGRID-ORCS; 119385; 10 hits in 189 CRISPR screens.
DR ChiTaRS; AGAP11; human.
DR GenomeRNAi; 119385; -.
DR Pharos; Q8TF27; Tdark.
DR PRO; PR:Q8TF27; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q8TF27; protein.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR Gene3D; 1.10.220.150; -; 1.
DR Gene3D; 1.25.40.20; -; 1.
DR Gene3D; 2.30.29.30; -; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00248; ANK; 2.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48403; SSF48403; 1.
DR SUPFAM; SSF57863; SSF57863; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW ANK repeat; GTPase activation; Metal-binding; Reference proteome; Repeat;
KW Zinc; Zinc-finger.
FT CHAIN 1..550
FT /note="Arf-GAP with GTPase, ANK repeat and PH domain-
FT containing protein 11"
FT /id="PRO_0000328758"
FT DOMAIN 121..307
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT DOMAIN 328..448
FT /note="Arf-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00288"
FT REPEAT 487..516
FT /note="ANK 1"
FT REPEAT 520..549
FT /note="ANK 2"
FT ZN_FING 343..366
FT /note="C4-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00288"
FT REGION 232..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..270
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 82
FT /note="I -> V (in dbSNP:rs2641563)"
FT /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.2"
FT /id="VAR_042518"
SQ SEQUENCE 550 AA; 60549 MW; A3A6A204B3ACC967 CRC64;
MTIISVTLEI HHHITERDAD RSLTILDEQL YSFAFSTVHI TKKRNGGGSL NNYSSSIPLT
PSTSQEDLYF SVPPTANTPT PICKQSMGWS NLFTSEKGSD PDKGRKALES HADTIGSGRA
IPIKQGMLLK RSGKWLKTWK KKYVTLCSNG VLTYYSSLGD YMKNIHKKEI DLRTSTIKVP
GKWPSLATSA CAPISSSKSN GLSKDMEALH MSANSDIGLG DSICFSPSIS STTSPKLNLP
PSPHANKKKH LKKKSTNNLK DDGLSSTAEE EEEKFMIVSV TGQTCHFKAT TYEERDAWVQ
AIQSQILASL QSCESSKSKS QLTSQSEAMA LQSIQNMRGN SHCVDCETQN PKWASLNLGV
LMCIECSGIH RSLGTRLSRV RSLELDDWPV ELRKVMSSIG NDLANSIWEG SSQGQTKPSI
ESTREEKERW IRSKYEHKLF LAPLPCTELS LGQHLLRATA DEDLRTAILL LAHGSREEVN
ETCGEGDGCT ALHLACRKGN VVLAQLLIWY GVDVMARDAH GNTALTYARQ ASSQECINVL
LQYGCPDECV